The use of lamotrigine, vigabatrin and gabapentin as add-on therapy in intractable epilepsy of childhood

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Show simple item record Madden, David (David Patrick) McDonald, Denise G. M. Najama, Y. Keegan, M.B. Whooley, M. McMenamin, Joseph B. 2008-10-21T14:28:28Z 2008-10-21T14:28:28Z Copyright 2004 BEA Trading Ltd. Published by Elsevier Ltd. en 2005
dc.identifier.citation Seizure - European Journal of Epilepsy en
dc.identifier.issn 1059-1311
dc.description.abstract Purpose: Lamotrigine (LTG), vigabatrin (VGB) and gabapentin (GBP) are three antiepileptic drugs (AEDs) used in the treatment of children with epilepsy for which longterm retention rates are not currently well known. This study examines the efficacy, long-term survival and adverse event profile of these three agents used as add-on therapy in children with refractory epilepsy over a 10-year period. Methods: Three separate audits were conducted between February 1996 and September 2000. All children studied had epilepsy refractory to other AEDs. Efficacy was confirmed if a patient became seizure free or achieved >50% reduction in seizure frequency for 6 months or more after starting therapy. Adverse events and patient survival for each drug were recorded at the end of the study period. Results: Between September 1990 and February 1996, 132 children received LTG, 80 VGB and 39 GBP. At the 10-year follow-up audit, 33% of the children on LTG had a sustained beneficial effect on their seizure frequency in contrast to 19% for VGB and 15% for GBP. No significant difference in efficacy was found in children with partial seizures. Children with epileptic encephalopathy (EE) including myoclonic-astatic epilepsy and Lennox—Gastaut Syndrome (LGS) achieved a more favorable response to LTG. The main reasons for drug withdrawal were lack of efficacy for VGB, apparent worsening of seizures for GBP and the development of a rash for LTG. Conclusions: Lamotrigine is a useful add-on therapy in treating children with epilepsy. It has a low adverse event profile and a sustained beneficial effect in children with intractable epilepsy. en
dc.format.extent 4304 bytes
dc.format.mimetype application/pdf
dc.language.iso en en
dc.publisher Elsevier Science en
dc.rights All rights reserved en
dc.rights.uri Publisher's copyright policy en
dc.rights.uri en
dc.subject Lamotrigine en
dc.subject Efficacy en
dc.subject Intractable en
dc.subject Childhood epilepsy en
dc.subject.lcsh Anticonvulsants--Effectiveness en
dc.subject.lcsh Epilepsy in children--Treatment en
dc.subject.mesh Epilepsy--drug therapy en
dc.subject.mesh Anticonvulsants--therapeutic use en
dc.title The use of lamotrigine, vigabatrin and gabapentin as add-on therapy in intractable epilepsy of childhood en
dc.type Journal Article en
dc.internal.authorurl David Madden (web page) en
dc.internal.authorurl en
dc.internal.authorcontactother Email:; Tel: 353-1-7168396 en
dc.internal.authorid UCD0014 en
dc.internal.availability Full text not available en
dc.internal.webversions Publisher's version en
dc.internal.webversions en
dc.status Peer reviewed en
dc.identifier.volume 14 en
dc.identifier.issue 2 en
dc.identifier.startpage 112 en
dc.identifier.endpage 116 en
dc.identifier.doi 10.1016/j.seizure.2004.12.001
dc.neeo.contributor Najama|Y.|aut|
dc.neeo.contributor Whooley|M.|aut|
dc.neeo.contributor Keegan|M.B.|aut|
dc.neeo.contributor Madden|David (David Patrick)|aut|UCD0014
dc.neeo.contributor McDonald|Denise G. M.|aut|
dc.neeo.contributor McMenamin|Joseph B.|aut|

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