Role of Genomics and RNA-seq in Studies of Fungal Virulence

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dc.contributor.author Riccombeni, Alessandro
dc.contributor.author Butler, Geraldine
dc.date.accessioned 2012-11-28T13:03:00Z
dc.date.available 2012-11-28T13:03:00Z
dc.date.copyright 2012 Springer Science+Business Media en
dc.date.issued 2012-09
dc.identifier.citation Current Fungal Infection Reports en
dc.identifier.issn 1936-3761
dc.identifier.uri http://hdl.handle.net/10197/3934
dc.description.abstract Since its introduction in the last decade, massive parallel sequencing, or "next-generation sequencing", has revolutionized our access to genomic information, providing accurate data with increasingly higher yields and lower costs with respect to first-generation technology. Massive parallel sequencing of cDNA, or RNA-seq, is progressively replacing array-based technology as the method of choice for transcriptomics. This review describes some of the most recent applications of next-generation sequencing technology to the study of pathogenic fungi, including Candida, Aspergillus and Cryptococcusspecies. Several integrated approaches illustrate the power and accuracy of RNA-seq for studying the biology of human fungal pathogens. In addition, the lack of consistency in data analysis is discussed. en
dc.language.iso en en
dc.publisher Springer en
dc.rights The final publication is available at springerlink.com en
dc.subject Aspergillus en
dc.subject Bioinformatics en
dc.subject Candida en
dc.subject ChIP-seq en
dc.subject Cryptococcus en
dc.subject Dermatophytes en
dc.subject Genomics en
dc.subject Next-generation sequencing en
dc.subject RNA-seq en
dc.subject.lcsh Nucleotide sequence en
dc.subject.lcsh Genomics en
dc.subject.lcsh Bioinformatics en
dc.subject.lcsh Aspergillus en
dc.subject.lcsh Candida en
dc.subject.lcsh Cryptococcus en
dc.subject.lcsh Dermatophytes en
dc.title Role of Genomics and RNA-seq in Studies of Fungal Virulence en
dc.type Journal Article en
dc.internal.authorcontactother alessandro.riccombeni@gmail.com
dc.internal.availability Full text available en
dc.internal.webversions http://www.springerlink.com/content/e37621502u258467/ en
dc.status Not peer reviewed en
dc.identifier.issue September 2012 en
dc.identifier.doi 10.1007/s12281-012-0104-z
dc.neeo.contributor Riccombeni|Alessandro|aut|
dc.neeo.contributor Butler|Geraldine|aut|
dc.description.admin Copyright: "It is fully accessible to all users at libraries and institutions that have purchased a SpringerLink license. If your article is published under one of our Open Access programs, it will be freely accessible to any user." Also, the journal is "Current Fungal Infection Reports", not the "Current Rheumatology" I used. This new journal was not on the list. Please add it. en
dc.description.admin Have asked Research for journal to be added (rmssupport@ucd.ie) 2012-11-23 JG en
dc.internal.rmsid 300782255
dc.date.updated 2012-09-19T14:25:10Z


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