Effect of dispersive conductivity and permittivity in volume conductor models of deep brain stimulation

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dc.contributor.author Grant, Peadar F.
dc.contributor.author Lowery, Madeleine M.
dc.date.accessioned 2012-10-09T15:11:15Z
dc.date.available 2012-10-09T15:11:15Z
dc.date.copyright 2010 IEEE en
dc.date.issued 2010-10
dc.identifier.citation IEEE Transactions on Biomedical Engineering en
dc.identifier.uri http://hdl.handle.net/10197/3846
dc.description.abstract The aim of this study was to examine the effect of dispersive tissue properties on the volume-conducted voltage waveforms and volume of tissue activated during deep brain stimulation. Inhomogeneous finite-element models were developed, incorporating a distributed dispersive electrode–tissue interface and encapsulation tissue of high and low conductivity, under both current controlled and voltage-controlled stimulation. The models were used to assess the accuracy of capacitive models, where material properties were estimated at a single frequency, with respect to the full dispersive models. The effect of incorporating dispersion in the electrical conductivity and relative permittivity was found to depend on both the applied stimulus and the encapsulation tissue surrounding the electrode. Under current-controlled stimulation, and during voltage-controlled stimulation when the electrode was surrounded by high-resistivity encapsulation tissue, the dispersive material properties of the tissue were found to influence the voltage waveform in the tissue, indicated by RMS errors between the capacitive and dispersive models of 20%–38% at short pulse durations. When the dispersive model was approximated by a capacitive model, the accuracy of estimates of the volume of tissue activated was very sensitive to the frequency at which material properties were estimated.When material properties at 1 kHz were used, the error in the volume of tissue activated by capacitive approximations was reduced to −4.33% and 11.10%, respectively, for current controlled and voltage-controlled stimulations, with higher errors observed when higher or lower frequencies were used. en
dc.language.iso en en
dc.publisher IEEE en
dc.rights © 2010 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. en
dc.subject Capacitance en
dc.subject Computational model en
dc.subject Deep brain stimulation (DBS) en
dc.subject Dispersion en
dc.subject.lcsh Brain stimulation en
dc.subject.lcsh Electric capacity en
dc.subject.lcsh Computer simulation en
dc.title Effect of dispersive conductivity and permittivity in volume conductor models of deep brain stimulation en
dc.type Journal Article en
dc.internal.authorcontactother peadar.grant@ucd.ie
dc.internal.availability Full text available en
dc.status Not peer reviewed en
dc.identifier.volume 57 en
dc.identifier.issue 10 en
dc.identifier.startpage 2386 en
dc.identifier.endpage 2393 en
dc.identifier.doi 10.1109/TBME.2010.2055054
dc.neeo.contributor Grant|Peadar F.|aut|
dc.neeo.contributor Lowery|Madeleine M.|aut|
dc.internal.rmsid 169365685
dc.date.updated 2012-09-12T09:58:15Z

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