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| dc.contributor.author | Amadio, Jessica | |
| dc.contributor.author | Murphy, Cormac D. | |
| dc.date.accessioned | 2012-09-04T15:59:46Z | |
| dc.date.available | 2012-09-04T15:59:46Z | |
| dc.date.copyright | 2009 Springer-Verlag | en |
| dc.date.issued | 2010 | |
| dc.identifier.citation | Applied Microbiology and Biotechnology | en |
| dc.identifier.uri | http://hdl.handle.net/10197/3782 | |
| dc.description.abstract | The fungus Cunninghamella elegans is a useful model of human catabolism of xenobiotics. In this paper, the biotransformation of fluorinated biphenyls by C. elegans was investigated by analysis of the culture supernatants with a variety of analytical techniques. 4-Fluorobiphenyl was principally transformed to 4-fluoro-4′-hydroxybiphenyl, but other mono- and dihydroxylated compounds were detected in organic extracts by gas chromatography–mass spectrometry. Additionally, fluorinated water-soluble products were detected by 19F NMR and were identified as sulphate and β-glucuronide conjugates. Other fluorobiphenyls (2-fluoro-, 4,4′-difluoro- and 2,3,4,5,6-pentafluoro-biphenyl) were catabolised by C. elegans, yielding mono- and dihydroxylated products, but phase II metabolites were detected from 4,4′-difluorobiphenyl only. | en |
| dc.description.sponsorship | Other funder | en |
| dc.language.iso | en | en |
| dc.publisher | Springer | en |
| dc.relation.requires | CSCB Research Collection | en |
| dc.rights | The final publication is available at www.springerlink.com | en |
| dc.subject | Fluorine | en |
| dc.subject | Biphenyl | en |
| dc.subject | Metabolism | en |
| dc.subject | F-19 NMR | en |
| dc.subject.lcsh | Fluorine | en |
| dc.subject.lcsh | Biphenyl compounds | en |
| dc.subject.lcsh | Biotransformation (Metabolism) | en |
| dc.subject.lcsh | Mucorales | en |
| dc.title | Biotransformation of fluorobiphenyl by Cunninghamella elegans | en |
| dc.type | Journal Article | en |
| dc.internal.availability | Full text available | en |
| dc.status | Peer reviewed | en |
| dc.identifier.volume | 86 | en |
| dc.identifier.issue | 1 | en |
| dc.identifier.startpage | 345 | en |
| dc.identifier.endpage | 351 | en |
| dc.identifier.doi | 10.1007/s00253-009-2346-4 | |
| dc.neeo.contributor | Amadio|Jessica|aut| | |
| dc.neeo.contributor | Murphy|Cormac D.|aut| | |
| dc.description.othersponsorship | EPA | en |
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