Biotransformation of fluorobiphenyl by Cunninghamella elegans

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dc.contributor.author Amadio, Jessica
dc.contributor.author Murphy, Cormac D.
dc.date.accessioned 2012-09-04T15:59:46Z
dc.date.available 2012-09-04T15:59:46Z
dc.date.copyright 2009 Springer-Verlag en
dc.date.issued 2010
dc.identifier.citation Applied Microbiology and Biotechnology en
dc.identifier.uri http://hdl.handle.net/10197/3782
dc.description.abstract The fungus Cunninghamella elegans is a useful model of human catabolism of xenobiotics. In this paper, the biotransformation of fluorinated biphenyls by C. elegans was investigated by analysis of the culture supernatants with a variety of analytical techniques. 4-Fluorobiphenyl was principally transformed to 4-fluoro-4′-hydroxybiphenyl, but other mono- and dihydroxylated compounds were detected in organic extracts by gas chromatography–mass spectrometry. Additionally, fluorinated water-soluble products were detected by 19F NMR and were identified as sulphate and β-glucuronide conjugates. Other fluorobiphenyls (2-fluoro-, 4,4′-difluoro- and 2,3,4,5,6-pentafluoro-biphenyl) were catabolised by C. elegans, yielding mono- and dihydroxylated products, but phase II metabolites were detected from 4,4′-difluorobiphenyl only. en
dc.description.sponsorship Other funder en
dc.language.iso en en
dc.publisher Springer en
dc.relation.requires CSCB Research Collection en
dc.rights The final publication is available at www.springerlink.com en
dc.subject Fluorine en
dc.subject Biphenyl en
dc.subject Metabolism en
dc.subject F-19 NMR en
dc.subject.lcsh Fluorine en
dc.subject.lcsh Biphenyl compounds en
dc.subject.lcsh Biotransformation (Metabolism) en
dc.subject.lcsh Mucorales en
dc.title Biotransformation of fluorobiphenyl by Cunninghamella elegans en
dc.type Journal Article en
dc.internal.availability Full text available en
dc.status Peer reviewed en
dc.identifier.volume 86 en
dc.identifier.issue 1 en
dc.identifier.startpage 345 en
dc.identifier.endpage 351 en
dc.identifier.doi 10.1007/s00253-009-2346-4
dc.neeo.contributor Amadio|Jessica|aut|
dc.neeo.contributor Murphy|Cormac D.|aut|
dc.description.othersponsorship EPA en
dc.internal.rmsid 134289184


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