Biotransformation of flurbiprofen by Cunninghamella species

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dc.contributor.author Amadio, Jessica
dc.contributor.author Gordon, Katherine
dc.contributor.author Murphy, Cormac D.
dc.date.accessioned 2012-09-04T15:26:57Z
dc.date.available 2012-09-04T15:26:57Z
dc.date.copyright 2010 American Society for Microbiology en
dc.date.issued 2010-09
dc.identifier.citation Applied and Environmental Microbiology en
dc.identifier.uri http://hdl.handle.net/10197/3780
dc.description.abstract The biotransformation of the fluorinated anti-inflammatory drug flurbiprofen was investigated in Cunninghamella spp. Mono- and di-hydroxylated metabolites were detected using gas chromatography-mass spectrometry and fluorine-19 nuclear magnetic resonance spectroscopy, and the major metabolite 4’-hydroxyflurbiprofen was isolated by preparative HPLC. C. elegans DSM 1908 and C. blakesleeana DSM 1906 also produced a phase II (conjugated) metabolite, which was identified as the sulfated drug via deconjugation experiments. en
dc.description.sponsorship Other funder en
dc.language.iso en en
dc.publisher American Society for Microbiology en
dc.subject Fluorine en
dc.subject.lcsh Anti-inflammatory agents en
dc.subject.lcsh Biotransformation (Metabolism) en
dc.subject.lcsh Mucorales en
dc.title Biotransformation of flurbiprofen by Cunninghamella species en
dc.type Journal Article en
dc.internal.availability Full text available en
dc.status Peer reviewed en
dc.identifier.volume 76 en
dc.identifier.issue 18 en
dc.identifier.startpage 6299 en
dc.identifier.endpage 6303 en
dc.identifier.doi 10.1128/AEM.01027-10
dc.neeo.contributor Amadio|Jessica|aut|
dc.neeo.contributor Gordon|Katherine|aut|
dc.neeo.contributor Murphy|Cormac D.|aut|
dc.description.othersponsorship Environmental Protection Agency en


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