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| dc.contributor.author | Amadio, Jessica | |
| dc.contributor.author | Gordon, Katherine | |
| dc.contributor.author | Murphy, Cormac D. | |
| dc.date.accessioned | 2012-09-04T15:26:57Z | |
| dc.date.available | 2012-09-04T15:26:57Z | |
| dc.date.copyright | 2010 American Society for Microbiology | en |
| dc.date.issued | 2010-09 | |
| dc.identifier.citation | Applied and Environmental Microbiology | en |
| dc.identifier.uri | http://hdl.handle.net/10197/3780 | |
| dc.description.abstract | The biotransformation of the fluorinated anti-inflammatory drug flurbiprofen was investigated in Cunninghamella spp. Mono- and di-hydroxylated metabolites were detected using gas chromatography-mass spectrometry and fluorine-19 nuclear magnetic resonance spectroscopy, and the major metabolite 4’-hydroxyflurbiprofen was isolated by preparative HPLC. C. elegans DSM 1908 and C. blakesleeana DSM 1906 also produced a phase II (conjugated) metabolite, which was identified as the sulfated drug via deconjugation experiments. | en |
| dc.description.sponsorship | Other funder | en |
| dc.language.iso | en | en |
| dc.publisher | American Society for Microbiology | en |
| dc.subject | Fluorine | en |
| dc.subject.lcsh | Anti-inflammatory agents | en |
| dc.subject.lcsh | Biotransformation (Metabolism) | en |
| dc.subject.lcsh | Mucorales | en |
| dc.title | Biotransformation of flurbiprofen by Cunninghamella species | en |
| dc.type | Journal Article | en |
| dc.internal.availability | Full text available | en |
| dc.status | Peer reviewed | en |
| dc.identifier.volume | 76 | en |
| dc.identifier.issue | 18 | en |
| dc.identifier.startpage | 6299 | en |
| dc.identifier.endpage | 6303 | en |
| dc.identifier.doi | 10.1128/AEM.01027-10 | |
| dc.neeo.contributor | Amadio|Jessica|aut| | |
| dc.neeo.contributor | Gordon|Katherine|aut| | |
| dc.neeo.contributor | Murphy|Cormac D.|aut| | |
| dc.description.othersponsorship | Environmental Protection Agency | en |
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