Biosynthesis of pyrrolylpolyenes in Auxarthron umbrinum

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dc.contributor.author Clark, Benjamin R.
dc.contributor.author Murphy, Cormac D.
dc.date.accessioned 2012-06-26T13:59:30Z
dc.date.available 2012-06-26T13:59:30Z
dc.date.copyright 2009 the authors en
dc.date.issued 2009
dc.identifier.citation Organic and Biomolecular Chemistry en
dc.identifier.uri http://hdl.handle.net/10197/3699
dc.description.abstract The biosynthesis of the pyrrolylpolyene rumbrin (1) in the fungus Auxarthron umbrinum was elucidated using feeding studies with labelled precursors. Incorporation of stable isotopes from [15N]-proline, [13C]-methionine and [13C]-acetate confirmed that these were the precursors of the pyrrole moiety, methyl groups, and backbone of rumbrin, respectively. Label-dilution experiments with pyrrole-2-carboxylate confirmed it was a direct precursor in the biosynthesis of rumbrin. Both 3- and 4-chloropyrrolecarboxylates were also accepted as precursors in polyene production. en
dc.description.sponsorship Irish Research Council for Science, Engineering and Technology en
dc.format.extent 6624 bytes
dc.format.extent 9933 bytes
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dc.format.extent 135680 bytes
dc.format.mimetype application/pdf
dc.format.mimetype application/pdf
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dc.language.iso en en
dc.publisher RSC Publishing en
dc.relation.requires CSCB Research Collection en
dc.subject Polyketide en
dc.subject.lcsh Polyketides--Synthesis en
dc.subject.lcsh Pyrroles--Synthesis en
dc.title Biosynthesis of pyrrolylpolyenes in Auxarthron umbrinum en
dc.type Journal Article en
dc.internal.availability Full text available en
dc.status Peer reviewed en
dc.identifier.volume 7 en
dc.identifier.issue 1 en
dc.identifier.startpage 111 en
dc.identifier.endpage 116 en
dc.identifier.doi 10.1039/B813236D
dc.neeo.contributor Clark|Benjamin R.|aut| en
dc.neeo.contributor Murphy|Cormac D.|aut| en
dc.description.admin au. kpw22/6/12 en


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