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| dc.contributor.author | Clark, Benjamin R. | |
| dc.contributor.author | Murphy, Cormac D. | |
| dc.date.accessioned | 2012-06-26T13:59:30Z | |
| dc.date.available | 2012-06-26T13:59:30Z | |
| dc.date.copyright | 2009 the authors | en |
| dc.date.issued | 2009 | |
| dc.identifier.citation | Organic and Biomolecular Chemistry | en |
| dc.identifier.uri | http://hdl.handle.net/10197/3699 | |
| dc.description.abstract | The biosynthesis of the pyrrolylpolyene rumbrin (1) in the fungus Auxarthron umbrinum was elucidated using feeding studies with labelled precursors. Incorporation of stable isotopes from [15N]-proline, [13C]-methionine and [13C]-acetate confirmed that these were the precursors of the pyrrole moiety, methyl groups, and backbone of rumbrin, respectively. Label-dilution experiments with pyrrole-2-carboxylate confirmed it was a direct precursor in the biosynthesis of rumbrin. Both 3- and 4-chloropyrrolecarboxylates were also accepted as precursors in polyene production. | en |
| dc.description.sponsorship | Irish Research Council for Science, Engineering and Technology | en |
| dc.format.extent | 6624 bytes | |
| dc.format.extent | 9933 bytes | |
| dc.format.extent | 6219 bytes | |
| dc.format.extent | 2596 bytes | |
| dc.format.extent | 6990 bytes | |
| dc.format.extent | 6992 bytes | |
| dc.format.extent | 9457 bytes | |
| dc.format.extent | 135680 bytes | |
| dc.format.mimetype | application/pdf | |
| dc.format.mimetype | application/pdf | |
| dc.format.mimetype | application/octet-stream | |
| dc.format.mimetype | application/octet-stream | |
| dc.format.mimetype | application/octet-stream | |
| dc.format.mimetype | application/octet-stream | |
| dc.format.mimetype | application/octet-stream | |
| dc.format.mimetype | application/msword | |
| dc.language.iso | en | en |
| dc.publisher | RSC Publishing | en |
| dc.relation.requires | CSCB Research Collection | en |
| dc.subject | Polyketide | en |
| dc.subject.lcsh | Polyketides--Synthesis | en |
| dc.subject.lcsh | Pyrroles--Synthesis | en |
| dc.title | Biosynthesis of pyrrolylpolyenes in Auxarthron umbrinum | en |
| dc.type | Journal Article | en |
| dc.internal.availability | Full text available | en |
| dc.status | Peer reviewed | en |
| dc.identifier.volume | 7 | en |
| dc.identifier.issue | 1 | en |
| dc.identifier.startpage | 111 | en |
| dc.identifier.endpage | 116 | en |
| dc.identifier.doi | 10.1039/B813236D | |
| dc.neeo.contributor | Clark|Benjamin R.|aut| | en |
| dc.neeo.contributor | Murphy|Cormac D.|aut| | en |
| dc.description.admin | au. kpw22/6/12 | en |
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