Biosynthesis of pyrrolylpolyenes in Auxarthron umbrinum

DSpace/Manakin Repository

Show simple item record Clark, Benjamin R. Murphy, Cormac D. 2012-06-26T13:59:30Z 2012-06-26T13:59:30Z 2009 the authors en 2009
dc.identifier.citation Organic and Biomolecular Chemistry en
dc.description.abstract The biosynthesis of the pyrrolylpolyene rumbrin (1) in the fungus Auxarthron umbrinum was elucidated using feeding studies with labelled precursors. Incorporation of stable isotopes from [15N]-proline, [13C]-methionine and [13C]-acetate confirmed that these were the precursors of the pyrrole moiety, methyl groups, and backbone of rumbrin, respectively. Label-dilution experiments with pyrrole-2-carboxylate confirmed it was a direct precursor in the biosynthesis of rumbrin. Both 3- and 4-chloropyrrolecarboxylates were also accepted as precursors in polyene production. en
dc.description.sponsorship Irish Research Council for Science, Engineering and Technology en
dc.format.extent 6624 bytes
dc.format.extent 9933 bytes
dc.format.extent 6219 bytes
dc.format.extent 2596 bytes
dc.format.extent 6990 bytes
dc.format.extent 6992 bytes
dc.format.extent 9457 bytes
dc.format.extent 135680 bytes
dc.format.mimetype application/pdf
dc.format.mimetype application/pdf
dc.format.mimetype application/octet-stream
dc.format.mimetype application/octet-stream
dc.format.mimetype application/octet-stream
dc.format.mimetype application/octet-stream
dc.format.mimetype application/octet-stream
dc.format.mimetype application/msword
dc.language.iso en en
dc.publisher RSC Publishing en
dc.relation.requires CSCB Research Collection en
dc.subject Polyketide en
dc.subject.lcsh Polyketides--Synthesis en
dc.subject.lcsh Pyrroles--Synthesis en
dc.title Biosynthesis of pyrrolylpolyenes in Auxarthron umbrinum en
dc.type Journal Article en
dc.internal.availability Full text available en
dc.status Peer reviewed en
dc.identifier.volume 7 en
dc.identifier.issue 1 en
dc.identifier.startpage 111 en
dc.identifier.endpage 116 en
dc.identifier.doi 10.1039/B813236D
dc.neeo.contributor Clark|Benjamin R.|aut| en
dc.neeo.contributor Murphy|Cormac D.|aut| en
dc.description.admin au. kpw22/6/12 en

This item appears in the following Collection(s)

Show simple item record

This item is available under the Attribution-NonCommercial-NoDerivs 3.0 Ireland. No item may be reproduced for commercial purposes. For other possible restrictions on use please refer to the publisher's URL where this is made available, or to notes contained in the item itself. Other terms may apply.

If you are a publisher or author and have copyright concerns for any item, please email and the item will be withdrawn immediately. The author or person responsible for depositing the article will be contacted within one business day.

Search Research Repository

Advanced Search