Role of cell cycle on the cellular uptake and dilution of nanoparticles in a cell population

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dc.contributor.author Kim, Jong Ah
dc.contributor.author Åberg, Christoffer
dc.contributor.author Salvati, Anna
dc.contributor.author Dawson, Kenneth A.
dc.date.accessioned 2012-06-21T15:51:16Z
dc.date.available 2012-06-21T15:51:16Z
dc.date.copyright © 2011 Nature Publishing Group en
dc.date.issued 2012-01
dc.identifier.citation Nature Nanotechnology en
dc.identifier.issn 1748-3387
dc.identifier.uri http://hdl.handle.net/10197/3695
dc.description.abstract Nanoparticles are considered a primary vehicle for targeted therapies because they can pass biological barriers, enter and distribute in cells by energy-dependent pathways1-3. Until now, most studies have shown that nanoparticle properties, such as size4-6 and surface7,8, can affect how cells internalise nanoparticles. Here we show that the different phases of cell growth, which constitute the cell cycle, can also influence nanoparticle uptake. Although cells in different cell cycle phases internalised nanoparticles with similar rates, after 24 hours of uptake the concentration of nanoparticles in the cells is ranked according to the different cell cycle phases: G2/M > S > G0/G1. Nanoparticles were not exported from cells but the internalised nanoparticle concentration is split when the cell divides. Our results suggest that future studies on nanoparticle uptake should consider the cell cycle because in a cell population, the internalised nanoparticle dose in each cell varies as the cell cycles. en
dc.description.sponsorship Science Foundation Ireland en
dc.description.sponsorship Higher Education Authority en
dc.description.sponsorship Irish Research Council for Science, Engineering and Technology en
dc.description.sponsorship European Research Council en
dc.format.extent 758628 bytes
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dc.language.iso en en
dc.publisher Nature Publishing Group en
dc.relation.requires Chemistry and Chemical Biology Research Colelction en
dc.relation.requires Conway Institute Research Collection en
dc.subject Nanoparticles en
dc.subject Cell cycle en
dc.subject.lcsh Nanoparticles en
dc.subject.lcsh Nanomedicine en
dc.subject.lcsh Cell cycle en
dc.title Role of cell cycle on the cellular uptake and dilution of nanoparticles in a cell population en
dc.type Journal Article en
dc.internal.availability Full text available en
dc.status Peer reviewed en
dc.identifier.volume 7 en
dc.identifier.issue 1 en
dc.identifier.startpage 62 en
dc.identifier.endpage 68 en
dc.identifier.doi 10.1038/nnano.2011.191
dc.neeo.contributor Kim|Jong Ah|aut|
dc.neeo.contributor Åberg|Christoffer|aut|
dc.neeo.contributor Salvati|Anna|aut|
dc.neeo.contributor Dawson|Kenneth A.|aut|
dc.description.admin 6M embargo: release after 6/05/2012 - 24/01/2012 AV en


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