Time and Space Resolved Uptake Study of Silica Nanoparticles by Human Cells

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dc.contributor.author Shapero, Kayle
dc.contributor.author Fenaroli, Federico
dc.contributor.author Lynch, Iseult
dc.contributor.author Cottell, David C.
dc.contributor.author Salvati, Anna
dc.contributor.author Dawson, Kenneth A.
dc.date.accessioned 2012-06-21T15:38:42Z
dc.date.available 2012-06-21T15:38:42Z
dc.date.copyright The Royal Society of Chemistry 2011 en
dc.date.issued 2011
dc.identifier.citation Molecular Biosystems en
dc.identifier.uri http://hdl.handle.net/10197/3694
dc.description.abstract A spatio-temporal mapping of the uptake of silica (SiO2) nanoparticles of different sizes by lung epithelial cells has been obtained. Based on high control of nanoparticle dispersion in cell media and cell exposure, one obtains reproducible and quantitative time-resolved data using a combination of flow cytometry, fluorescence and electron microscopies. We are thereby able to give a rather detailed account of the journey of SiO2 nanoparticles from the early events of uptake to their final sub-cellular localization. en
dc.description.sponsorship Science Foundation Ireland en
dc.description.sponsorship Irish Research Council for Science, Engineering and Technology en
dc.description.sponsorship European Research Council en
dc.format.extent 1398564 bytes
dc.format.extent 1584805 bytes
dc.format.mimetype application/pdf
dc.format.mimetype application/pdf
dc.language.iso en en
dc.publisher Royal Society of Chemistry en
dc.subject Silica en
dc.subject Nanoparticle uptake en
dc.subject Flow cytometry en
dc.subject Transmission electronmicroscopy en
dc.subject.lcsh Silica en
dc.subject.lcsh Nanoparticles en
dc.subject.lcsh Flow cytometry en
dc.subject.lcsh Transmission electron microscopy en
dc.title Time and Space Resolved Uptake Study of Silica Nanoparticles by Human Cells en
dc.type Journal Article en
dc.internal.availability Full text available en
dc.status Peer reviewed en
dc.identifier.volume 7 en
dc.identifier.issue 2 en
dc.identifier.startpage 371 en
dc.identifier.endpage 378 en
dc.identifier.doi 10.1039/C0MB00109K
dc.neeo.contributor Shapero|Kayle|aut| en
dc.neeo.contributor Fenaroli|Federico|aut| en
dc.neeo.contributor Lynch|Iseult|aut| en
dc.neeo.contributor Cottell|David C.|aut| en
dc.neeo.contributor Salvati|Anna|aut| en
dc.neeo.contributor Dawson|Kenneth A.|aut| en
dc.description.othersponsorship EPA en
dc.description.admin 12M embargo has expired - 24/01/2012 AV en

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