One-step diketopiperazine synthesis using phase transfer catalysis

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dc.contributor.author O'Reilly, Elaine
dc.contributor.author Lestini, Elena
dc.contributor.author Balducci, Daniele
dc.contributor.author Paradisi, Francesca
dc.date.accessioned 2012-06-13T15:25:46Z
dc.date.available 2012-06-13T15:25:46Z
dc.date.copyright 2009 Elsevier en
dc.date.issued 2009-04-15
dc.identifier.citation Tetrahedron Letters en
dc.identifier.uri http://hdl.handle.net/10197/3638
dc.description.abstract A simple and efficient one-step procedure is described for the synthesis of a number of symmetrical 1,4-disubstituted piperazine-2,5-diones under phase transfer conditions. The reactions are carried out at room temperature, starting from a suitable N-chloroacetamide in the presence of an aqueous solution of sodium hydroxide. Piperazine-2,5-diones were obtained with excellent selectivity in yields of up to 90%. en
dc.description.sponsorship Higher Education Authority en
dc.description.sponsorship Irish Research Council for Science, Engineering and Technology en
dc.format.extent 312320 bytes
dc.format.mimetype application/msword
dc.language.iso en en
dc.publisher Elsevier en
dc.rights This is the author’s version of a work that was accepted for publication in Tetrahedron Letters. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Tetrahedron Letters (2009) DOI: 10.1016/j.tetlet.2009.01.146 en
dc.subject Diketopiperazine en
dc.subject Chloroacetamide en
dc.subject Phase transfer catalyst en
dc.subject TEBA en
dc.subject.lcsh Organic cyclic compounds--Synthesis en
dc.subject.lcsh Phase-transfer catalysts en
dc.title One-step diketopiperazine synthesis using phase transfer catalysis en
dc.type Journal Article en
dc.internal.availability Full text available en
dc.status Peer reviewed en
dc.identifier.volume 50 en
dc.identifier.issue 15 en
dc.identifier.startpage 1748 en
dc.identifier.endpage 1750 en
dc.identifier.doi 10.1016/j.tetlet.2009.01.146
dc.neeo.contributor O'Reilly|Elaine|aut| en
dc.neeo.contributor Lestini|Elena|aut| en
dc.neeo.contributor Balducci|Daniele|aut| en
dc.neeo.contributor Paradisi|Francesca|aut| en


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