A simple and efficient method for the synthesis of Erlenmeyer azlactones

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dc.contributor.author Conway, Philip A.
dc.contributor.author Devine, Kevin
dc.contributor.author Paradisi, Francesca
dc.date.accessioned 2012-06-13T13:57:31Z
dc.date.available 2012-06-13T13:57:31Z
dc.date.copyright 2009 Elsevier en
dc.date.issued 2009-04-11
dc.identifier.citation Tetrahedron en
dc.identifier.uri http://hdl.handle.net/10197/3637
dc.description.abstract We have recently developed a novel and efficient method for synthesising Erlenmeyer azlactones under mild and rapid conditions. The reaction is performed by reacting 2-phenyl-5-oxazolone with an aldehyde in dichloromethane using alumina as a catalyst. The materials react instantly at room temperature, negating the need for high temperatures and long reaction times. We have successfully used this method for both aliphatic, aromatic and heteroaromatic aldehydes, synthesising previously unmade Erlenmeyer azlactones in moderate to high yields. en
dc.description.sponsorship Science Foundation Ireland en
dc.format.extent 192512 bytes
dc.format.mimetype application/msword
dc.language.iso en en
dc.publisher Elsevier en
dc.rights This is the author’s version of a work that was accepted for publication in Tetrahedron. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Tetrahedron (2009) DOI: 10.1016/j.tet.2009.02.011 en
dc.subject Aromatic azlactones en
dc.subject Aliphatic azlactones en
dc.subject solid-phase catalysis en
dc.subject.lcsh Aromatic compounds en
dc.subject.lcsh Aliphatic compounds en
dc.subject.lcsh Solid-phase synthesis en
dc.title A simple and efficient method for the synthesis of Erlenmeyer azlactones en
dc.type Journal Article en
dc.internal.availability Full text available en
dc.status Peer reviewed en
dc.identifier.volume 65 en
dc.identifier.issue 15 en
dc.identifier.startpage 2935 en
dc.identifier.endpage 2938 en
dc.identifier.doi 10.1016/j.tet.2009.02.011
dc.neeo.contributor Conway|Philip A.|aut| en
dc.neeo.contributor Devine|Kevin|aut| en
dc.neeo.contributor Paradisi|Francesca|aut| en

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