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dc.contributor.author Puri, Prem
dc.contributor.author Gosemann, Jan-Hendrik
dc.contributor.author Darlow, John
dc.contributor.author Barton, David E.
dc.date.accessioned 2011-10-14T15:30:50Z
dc.date.available 2011-10-14T15:30:50Z
dc.date.copyright 2011 Nature Publishing Group en
dc.date.issued 2011-10
dc.identifier.citation Nature Reviews Urology en
dc.identifier.issn 1759-4812
dc.identifier.uri http://hdl.handle.net/10197/3231
dc.description.abstract Primary vesicoureteral reflux (VUR) is the most common urological anomaly in children, affecting 1–2% of the pediatric population and 30–40% of children presenting with urinary tract infections (UTIs). Refluxassociated nephropathy is a major cause of childhood hypertension and chronic renal failure. The hereditary and familial nature of VUR is well recognized and several studies have reported that siblings of children with VUR have a higher incidence of reflux than the general pediatric population. Familial clustering of VUR implies that genetic factors have an important role in its pathogenesis, but no single major locus or gene for VUR has yet been identified and most researchers now acknowledge that VUR is genetically heterogeneous. Improvements in genome-scan techniques and continuously increasing knowledge of the genetic basis of VUR should help us to further understand its pathogenesis. en
dc.description.sponsorship Other funder en
dc.format.extent 833914 bytes
dc.format.mimetype application/pdf
dc.language.iso en en
dc.publisher Nature Publishing Group en
dc.subject Vesicoureteral en
dc.subject Reflux en
dc.subject Genetics en
dc.subject Mapping en
dc.subject Linkage en
dc.subject Nephropathy en
dc.subject.lcsh Vesico-ureteral reflux in children en
dc.subject.lcsh Vesico-ureteral reflux--Genetic aspects en
dc.subject.lcsh Gene mapping en
dc.subject.mesh Vesico-Ureteral Reflux-- genetics en
dc.subject.mesh Chromosome Mapping en
dc.title Genetics of vesicoureteral reflux en
dc.type Review en
dc.internal.availability Full text available en
dc.internal.webversions Publisher's version en
dc.internal.webversions http://dx.doi.org/10.1038/nrurol.2011.113 en
dc.status Peer reviewed en
dc.identifier.volume 8 en
dc.identifier.issue 10 en
dc.identifier.startpage 539 en
dc.identifier.endpage 552 en
dc.identifier.doi 10.1038/nrurol.2011.113
dc.neeo.contributor Puri|Prem|aut| en
dc.neeo.contributor Gosemann|Jan-Hendrik|aut| en
dc.neeo.contributor Darlow|John|aut| en
dc.neeo.contributor Barton|David E.|aut| en
dc.description.othersponsorship Children's Medical and Research Foundation en
dc.description.admin 6M embargo after publication - AV 8/9/2011 ke, SB-09/09/2011 en


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