Browsing College of Health Sciences by Subject "Peptides"

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CycloPs : generating virtual libraries of cyclized and constrained peptides including nonnatural amino acids

Duffy, Fergal J. ; Verniere, Mélanie ; Devocelle, Marc ; Bernard, Elise ; Shields, Denis C. ; Chubb, Anthony J. (ACS Publications, 2011-03-24)

We introduce CycloPs, software for the generation of virtual libraries of constrained peptides including natural and nonnatural commercially available amino acids. The software is written in the cross-platform Python ...
Profile-based short linear protein motif discovery

Haslam, Niall J. ; Shields, Denis C. (BioMed Central Ltd, 2012-05-18)

Background: Short linear protein motifs are attracting increasing attention as functionally independent sites, typically 3-10 amino acids in length that are enriched in disordered regions of proteins. Multiple methods have ...
Towards the Improved Discovery and Design of Functional Peptides: Common Features of Diverse Classes Permit Generalized Prediction of Bioactivity

Mooney, Catherine ; Haslam, Niall J. ; Pollastri, Gianluca ; Shields, Denis C. (PLOS, 2012-10)

The conventional wisdom is that certain classes of bioactive peptides have specific structural features that endow their particular functions. Accordingly, predictions of bioactivity have focused on particular subgroups, ...