Prion diseases are characterized by the accumulation of PrP(Sc), an aberrantly folded isoform of the host protein PrP(C). Specific forms of synthetic molecules known as dendrimers are able to eliminate protease-resistant ...
Accumulation of PrP(Sc), an insoluble and protease-resistant pathogenic isoform of the cellular prion protein (PrP(C)), is a hallmark in prion diseases. Branched polyamines, including PPI (poly(propylene imine)) dendrimers, ...
A panel of repetitively branched synthetic molecules known as dendrimers is used to identify and differentiate between different strains of the prion infectious agent, the protein-based pathogen responsible for prion ...
Prion diseases, also known
as transmissible spongiform encephalopathies, are a group of fatal
neurodegenerative diseases that include scrapie in sheep, bovine spongiform encephalopathy
(BSE) in cattle and Creutzfeldt-Jakob ...
Upland headwater streams are dynamic systems, responding rapidly to changes in climatic conditions. This study examined the effects of a catastrophic rainfall event, that occured on 24 October 2011 on the east coast of ...