Browsing CSCB Research Collection by Author "Murphy, Cormac D."

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Browsing CSCB Research Collection by Author

Browsing CSCB Research Collection by Author "Murphy, Cormac D."

Now showing items 1-7 of 7

Bacterial defluorination of 4-fluoroglutamic acid

Donnelly, Clár ; Murphy, Cormac D. (Springer, 2007)

Fluorinated amino acids are used as enzyme inhibitors, mechanistic probes and in the production of pharmacologically active peptides. Because enantiomerically pure 4-fluoroglutamate is difficult to prepare, the selective ...
Biosynthesis of pyrrolylpolyenes in Auxarthron umbrinum

Clark, Benjamin R. ; Murphy, Cormac D. (RSC Publishing, 2009)

The biosynthesis of the pyrrolylpolyene rumbrin (1) in the fungus Auxarthron umbrinum was elucidated using feeding studies with labelled precursors. Incorporation of stable isotopes from [15N]-proline, [13C]-methionine and ...
Biotransformation of fluorobiphenyl by Cunninghamella elegans

Amadio, Jessica ; Murphy, Cormac D. (Springer, 2010)

The fungus Cunninghamella elegans is a useful model of human catabolism of xenobiotics. In this paper, the biotransformation of fluorinated biphenyls by C. elegans was investigated by analysis of the culture supernatants ...
Comparison of planktonic and biofilm cultures of Pseudomonas fluorescens DSM 8341 cells grown on fluoroacetate

Heffernan, Barry ; Murphy, Cormac D. ; Casey, Eoin (American Society for Microbiology, 2009-05)

Comparisons between the physiological properties of Pseudomonas fluorescens biofilm cells grown in a tubular biofilm reactor and planktonic cells grown in a chemostat were performed. Fluoroacetate was the sole carbon source ...
Precursor-directed biosynthesis of fluorinated iturin A in Bacillus spp.

Moran, Stephen ; Rai, Dilip K. ; Clark, Benjamin R. ; Murphy, Cormac D. (RSC Publishing, 2009)

Some iturin A-producing strains of Bacillus subtilis will elaborate the novel fluorinated analogue when incubated with 3-fluoro-L-tyrosine. The activity of iturin A is dependent on the D-tyrosine residue and the presence ...
Purification and properties of fluoroacetate dehalogenase from Pseudomonas fluorescens DSM 8341

Donnelly, Clár ; Murphy, Cormac D. (Springer, 2009)

The degradation of fluoroacetate by microorganisms has been established for some time, although only a handful of dehalogenases capable of hydrolyzing the stable C-F bond have been studied. The bacterium Pseudomonas ...
Treatment of fluoroacetate by a Pseudomonas fluorescens biofilm grown in membrane aerated biofilm reactor

Heffernan, Barry ; Murphy, Cormac D. ; Syron, Eoin ; Casey, Eoin (ACS Publications, 2009)

Fluorinated organic compounds have widespread applications, and their accumulation in the environment is a concern. Biofilm reactors are an effective technology for the treatment of contaminated wastewater, yet almost no ...