Background problem alcohol use is common among problem drug users (PDU) and associated with adverse health outcomes. Primary care has an important role in the overall stepped approach to alcohol treatment, especially ...
We introduce CycloPs, software for the generation of virtual libraries of
constrained peptides including natural and nonnatural commercially available amino acids.
The software is written in the cross-platform Python ...
Linear motifs are short, evolutionarily plastic components of regulatory proteins and provide low-affinity interaction interfaces. These compact modules play central roles in mediating every aspect of the regulatory ...
Problem alcohol use (PAU) is common among drug users (DUs) prevalence rates vary from 13-76%, in a recent Irish study of patients on methadone 35% had an AUDIT score indicating PAU. PAU is associated with adverse health ...
Primary vesicoureteral reflux (VUR) is the most common urological anomaly in children, affecting
1–2% of the pediatric population and 30–40% of children presenting with urinary tract infections (UTIs). Refluxassociated
...
Introduction: Child abuse is often underreported by the general population and healthcare professionals for a variety of reasons and, therefore, all avenues to improve the discovery and prevention of child abuse should be ...
Problem alcohol use is common among drug using patients who attend GPs in Ireland (35%) and other European countries. It is associated with adverse health outcomes including physical, psychological and social implications. ...
Sequencing by hybridisation is an effective method for obtaining large amounts of
DNA sequence information at low cost. The efficiency of SBH depends on
the design of the probe library to provide the maximum information ...
Short linear motifs in proteins (typically 3–12 residues in length) play key roles in protein–protein interactions by frequently binding specifically to peptide binding domains within interacting proteins. Their tendency ...
The ability of docking to predict angiotensin converting enzyme (ACE) inhibitory dipeptide sequences was assessed using AutoDock Vina. All potential dipeptides and phospho-dipeptides were docked and scored. Peptide intestinal ...
Introduction: Problem alcohol use is common and associated with considerable adverse health and social outcomes among patients who attend GPs in Ireland and other European countries for opioid substitution treatment. This ...
Background: Short linear protein motifs are attracting increasing attention as functionally independent sites, typically 3-10 amino acids in length that are enriched in disordered regions of proteins. Multiple methods have ...
Background
Short linear protein motifs are attracting increasing attention as functionally independent sites, typically 3-10 amino acids in length that are enriched in disordered regions of proteins. Multiple methods ...
Intracellular juxtamembrane regions of transmembrane proteins play pivotal roles in cell signalling, mediated by protein-protein interactions. Disordered protein regions, and short conserved motifs within them, are emerging ...
This is the protocol for a review and there is no abstract. The objectives are as follows:To determine the effectiveness of psychosocial interventions targeting problem alcohol use versus other treatments in illicit drug users.
Background: Problem alcohol use is common among illicit drug users and is associated with adverse health outcomes. It is also an important factor in poor prognosis among drug users with hepatitis C virus (HCV) as it impacts ...
Since its introduction in the last decade, massive parallel sequencing, or "next-generation sequencing", has revolutionized our access to genomic information, providing accurate data with increasingly higher yields and ...
Equine navicular syndrome (ENS) is a common ailment
responsible for up to one-third of all chronic forelimb
lameness. The current presentation, based on literature
reviews and veterinary and radiology opinions, offers ...