Browsing Conway Institute Research Collection by Author "Pollastri, Gianluca"

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Prediction of short linear protein binding regions

Mooney, Catherine ; Pollastri, Gianluca ; Shields, Denis C. ; Haslam, Niall J. (Elsevier, 2012-01-06)

Short linear motifs in proteins (typically 3–12 residues in length) play key roles in protein–protein interactions by frequently binding specifically to peptide binding domains within interacting proteins. Their tendency ...
SCLpred : protein subcellular localization prediction by N-to-1 neural networks

Mooney, Catherine ; Wang, Yong-Hong ; Pollastri, Gianluca (Oxford University Press, 2011-08-27)

Knowledge of the subcellular location of a protein provides valuable information about its function and possible interaction with other proteins. In the post-genomic era, fast and accurate predictors of subcellular location ...
Towards the Improved Discovery and Design of Functional Peptides: Common Features of Diverse Classes Permit Generalized Prediction of Bioactivity

Mooney, Catherine ; Haslam, Niall J. ; Pollastri, Gianluca ; Shields, Denis C. (PLOS, 2012-10)

The conventional wisdom is that certain classes of bioactive peptides have specific structural features that endow their particular functions. Accordingly, predictions of bioactivity have focused on particular subgroups, ...