Browsing Conway Institute Research Collection by Author "Kelley-Hickie, Leanne P."

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Homologous desensitization of signalling by the beta isoform of the human thromboxane A2 receptor

Kelley-Hickie, Leanne P. ; Kinsella, B. Therese (Elsevier, 2006-09)

Thromboxane (TX) A2 is a potent stimulator of platelet activation/aggregation and smooth muscle contraction and contributes to a variety of pathologies within the vasculature. In this study, we investigated the mechanism ...
Prostaglandin D2 receptor-mediated desensitization of the alpha isoform of the human thromboxane A2 receptor

Foley, John F. ; Kelley-Hickie, Leanne P. ; Kinsella, B. Therese (Elsevier, 2001-07-15)

Thromboxane (TX) A2 and prostaglandin (PG) D2 mediate opposing actions in platelets and in vascular and non-vascular smooth muscle. Here, we investigated the effects of stimulation of the PGD2 receptor (DP) on signaling ...
The role of N-linked glycosylation in determining the surface expression, G protein interaction and effector coupling of the alpha isoform of the human thromboxane A2 receptor

Kelley-Hickie, Leanne P. ; Kinsella, B. Therese (Elsevier, 2003-05-02)

In humans, thromboxane (TX) A2 signals through two TXA2 receptor (TP) isoforms, termed TPalpha and TPbeta, that diverge exclusively within their carboxyl terminal cytoplasmic domains. The amino terminal extracellular ...

Now showing items 1-3 of 3