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Browsing Conway Institute Research Collection by Title

Browsing Conway Institute Research Collection by Title

Now showing items 11-30 of 46

High-mobility group box protein 1: a novel mediator of inflammatory-induced renal epithelial-mesenchymal transition

Lynch, Julie ; Nolan, Stephen ; Slattery, Craig ; Feighery, Ronan ; Ryan, Michael P. ; McMorrow, Tara (Karger, 2010-11-24)

Background: High mobility group box protein 1 (HMGB-1) is a chromatin binding protein that bends DNA thereby facilitating gene transcription. HMGB-1 has also been observed as an extracellular secreted protein in serum of ...
Homologous desensitization of signalling by the beta isoform of the human thromboxane A2 receptor

Kelley-Hickie, Leanne P. ; Kinsella, B. Therese (Elsevier, 2006-09)

Thromboxane (TX) A2 is a potent stimulator of platelet activation/aggregation and smooth muscle contraction and contributes to a variety of pathologies within the vasculature. In this study, we investigated the mechanism ...
Identification of an interaction between the TPalpha and TPbeta isoforms of the human thromboxane A2 receptor with protein kinase C-related kinase (PRK) 1 : implications for prostate cancer.

Turner, Elizebeth C. ; Kavanagh, David J. ; Mulvaney, Eamon P. ; McLean, Caitriona ; Wikström, Katarina ; Reid, Helen M. ; Kinsella, B. Therese (American Society for Biochemistry and Molecular Biology, 2011-04-29)

In humans, thromboxane (TX)A2 signals through the TPalpha and TPbeta isoforms of the TXA2 receptor, or TP. Herein, the RhoA effector protein kinase C-related kinase (PRK) 1 was identified as an interactant of both TPalpha ...
Identification of a novel endoplasmic reticulum export motif within the eighth alpha-helical domain (alpha-H8) of the human prostacyclin receptor

Donnellan, Peter D. ; Kimbembe, Cisca C. ; Reid, Helen M. ; Kinsella, B. Therese (Elsevier, 2011-04)

The human prostacyclin receptor (hIP) undergoes agonist-dependent trafficking involving a direct interaction with Rab11a GTPase. The region of interaction was localised to a 14 residue Rab11a binding domain (RBD) within ...
Identification of novel indicators of cyclosporine A nephrotoxicity in a CD-1 mouse model

O'Connell, Séin ; Slattery, Craig ; Ryan, Michael P. ; McMorrow, Tara (Elsevier, 2011-04-15)

The calcineurin inhibitor cyclosporine A (CsA) is a widely used immunosuppressive agent. However,nephrotoxicity is a serious side effect observed in patients which limits clinical use of CsA. CsA nephrotoxicity is associated ...
Identification of β2-microglobulin as a urinary biomarker for chronic allograft nephropathy using proteomic methods

Johnston, Olwyn ; Cassidy, Hilary ; O'Connell, Séin ; O'Riordan, Aisling ; Gallagher, William ; Maguire, Patricia B. ; Wynne, Kieran ; Cagney, Gerard ; Ryan, Michael P. ; Conlon, Peter J. ; McMorrow, Tara (Wiley, 2011-08)

Chronic allograft nephropathy (CAN) remains the leading cause of renal graft loss after the first year following renal transplantation. This study aimed to identify novel urinary proteomic profiles, which could distinguish ...
Interaction of angio-associated migratory cell protein with the TPα and TPβ isoforms of the human thromboxane A2 receptor

Reid, Helen M. ; Wikström, Katarina ; Kavanagh, David J. ; Mulvaney, Eamon P. ; Kinsella, B. Therese (Elsevier, 2011-04)

In humans, thromboxane (TX) A2 signals through the TPα and TPβ isoforms of its G-protein coupled TXA2 receptor (TP) to mediate a host of (patho)physiologic responses. Herein, angio-associated migratory cell protein (AAMP) ...
Interaction of the human prostacyclin receptor with the PDZ adapter protein PDZK : role in endothelial cell migration and angiogenesis

Turner, Elizebeth C. ; Mulvaney, Eamon P. ; Reid, Helen M. ; Kinsella, B. Therese (American Society for Cell Biology, 2011-06-08)

Prostacyclin is increasingly implicated in re-endothelialization and angiogenesis but through largely unknown mechanisms. Herein, the HDL scavenger receptor class B, type 1 (SR-B1) adapter protein PDZ domain-containing ...
Investigation of the role of the carboxyl terminal tails of the alpha and beta isoforms of the human thromboxane A2 receptor (TP) in mediating receptor : effector coupling

Walsh, Marie-Therese ; Foley, John F. ; Kinsella, B. Therese (Elsevier, 2000-04-17)

We have investigated the functional coupling of alpha and beta isoforms of the human thromboxane A2 receptor (TP) to Galpha16 and Galpha12 members of the Gq and G12 families of heterotrimeric G proteins in human embryonic ...
Lipoxins : regulators of resolution

Ryan, Aidan ; Godson, Catherine (Elsevier, 2010-04)

Persistent inflammation underlies many of the most prevalent diseases in the developed world including atherosclerosis and diabetes. There is a growing appreciation that inflammation and its active resolution may be ...
Mechanisms of calcineurin inhibitor nephrotoxicity in chronic allograft injury

Slattery, Craig ; Cassidy, Hilary ; Johnston, Olwyn ; Ryan, Michael P. ; McMorrow, Tara (Intech, 2012)

The first successful transplantation of a human kidney was performed more than 50 years ago by Murray and colleagues in 1954 between identical twins. The success of this transplantation was due to the fact that no significant ...
Oxygen-mediated regulation of biofilm development is controlled by the alternative sigma factor sigma(B) in Staphylococcus epidermidis

Cotter, John J. ; O'Gara, James P. ; Mack, Dietrich ; Casey, Eoin (ASM, 2009-01)

Using a modified rotating-disk reactor to sparge oxygen to Staphylococcus epidermidis cultures, we found that oxygen negatively regulates biofilm development by influencing the activity of {sigma}B. Under anaerobic conditions, ...
Predicting the open conformations of protein kinases using molecular dynamics simulations

Bjarnadottir, Una ; Nielsen, Jens Erik (Wiley-Blackwell, 2012-01)

Protein kinases (PK) control phosphorylation in eukaryotic cells, and thereby regulate metabolic pathways, cell cycle progression, apoptosis and transcription. Consequently there is significant interest in manipulating ...
Prediction of short linear protein binding regions

Mooney, Catherine ; Pollastri, Gianluca ; Shields, Denis C. ; Haslam, Niall J. (Elsevier, 2012-01-06)

Short linear motifs in proteins (typically 3–12 residues in length) play key roles in protein–protein interactions by frequently binding specifically to peptide binding domains within interacting proteins. Their tendency ...
Predictive modelling of angiotensin converting enzyme inhibitory dipeptides

Norris, Roseanne ; Casey, Fergal ; FitzGerald, Richard ; Shields, Denis C. ; Mooney, Catherine (Elsevier, 2012-08-14)

The ability of docking to predict angiotensin converting enzyme (ACE) inhibitory dipeptide sequences was assessed using AutoDock Vina. All potential dipeptides and phospho-dipeptides were docked and scored. Peptide intestinal ...
Principles of Electrospray Ionization

Wilm, M (American Society for Biochemistry and Molecular Biology, 2011-05-19)

Electrospray ionization is today the most widely used ionization technique in chemical and bio-chemical analysis. Interfaced with a mass spectrometer it allows to investigate the molecular composition of liquid samples. ...
Profile-based short linear protein motif discovery.

Haslam, Niall J. ; Shields, Denis C. (BioMed Central, 2012-05-18)

Background Short linear protein motifs are attracting increasing attention as functionally independent sites, typically 3-10 amino acids in length that are enriched in disordered regions of proteins. Multiple methods ...
Prostaglandin D2 receptor-mediated desensitization of the alpha isoform of the human thromboxane A2 receptor

Foley, John F. ; Kelley-Hickie, Leanne P. ; Kinsella, B. Therese (Elsevier, 2001-07-15)

Thromboxane (TX) A2 and prostaglandin (PG) D2 mediate opposing actions in platelets and in vascular and non-vascular smooth muscle. Here, we investigated the effects of stimulation of the PGD2 receptor (DP) on signaling ...
Quantitative proteomics in biological research

Wilm, Matthias (Wiley, 2009-10)

Proteomics has enabled the direct investigation of biological material, at first through the analysis of individual proteins, then of lysates from cell cultures, and finally of extracts from tissues and biopsies from entire ...
Rapid depletion of dissolved oxygen in 96 well microtitre plate Staphylococcus epidermidis biofilm assays promotes biofilm development and is influenced by inoculum cell concentration

Cotter, John J. ; O'Gara, James P. ; Casey, Eoin (Wiley, 2009-08-01)

Biofilm-related research using 96-well microtiter plates involves static incubation of plates indiscriminate of environmental conditions, making oxygen availability an important variable which has not been considered to ...