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Now showing items 29-46 of 46

Quantitative proteomics in biological research

Wilm, Matthias (Wiley, 2009-10)

Proteomics has enabled the direct investigation of biological material, at first through the analysis of individual proteins, then of lysates from cell cultures, and finally of extracts from tissues and biopsies from entire ...
Rapid depletion of dissolved oxygen in 96 well microtitre plate Staphylococcus epidermidis biofilm assays promotes biofilm development and is influenced by inoculum cell concentration

Cotter, John J. ; O'Gara, James P. ; Casey, Eoin (Wiley, 2009-08-01)

Biofilm-related research using 96-well microtiter plates involves static incubation of plates indiscriminate of environmental conditions, making oxygen availability an important variable which has not been considered to ...
Recycling of the human prostacyclin receptor is regulated through a direct interaction with Rab11a GTPase

Wikström, Katarina ; Reid, Helen M. ; Hill, Maria ; English, Karol A. ; O'Keeffe, Martina B. ; Kimbembe, Cisca C. ; Kinsella, B. Therese (Elsevier, 2008-12)

The human prostacyclin receptor (hIP) undergoes agonist-induced internalization but the mechanisms regulating its intracellular trafficking and/or recycling to the plasma membrane are poorly understood. Herein, we conducted ...
Regulated expression of the α isoform of the human thromboxane A2 receptor during megakaryocyte differentiation : a coordinated role for WT1, Egr1 & Sp1

Gannon, AnneMarie ; Turner, Elizebeth C. ; Reid, Helen M. ; Kinsella, B. Therese (Elsevier, 2009-11-20)

Thromboxane plays an essential role in haemostasis, regulating platelet aggregation and vessel tone. In humans, it signals through the TPalpha and TPbeta isoforms that are transcriptionally regulated by distinct promoters, ...
Role of cell cycle on the cellular uptake and dilution of nanoparticles in a cell population

Kim, Jong Ah ; Åberg, Christoffer ; Salvati, Anna ; Dawson, Kenneth A. (Nature Publishing Group, 2012-01)

Nanoparticles are considered a primary vehicle for targeted therapies because they can pass biological barriers, enter and distribute in cells by energy-dependent pathways1-3. Until now, most studies have shown that ...
The Role of MAPK in Drug-Induced Kidney Injury

Cassidy, Hilary ; Radford, Robert ; Slyne, Jennifer ; O'Connell, Sein ; Slattery, Craig ; Ryan, Michael P. ; McMorrow, Tara (Hindawi Publishers, 2012)

This paper focuses on the role that mitogen-activated protein kinases (MAPKs) play in drug-induced kidney injury. The MAPKs, of which there are four major classes (ERK, p38, JNK, and ERK5/BMK), are signalling cascades ...
The role of N-linked glycosylation in determining the surface expression, G protein interaction and effector coupling of the alpha isoform of the human thromboxane A2 receptor

Kelley-Hickie, Leanne P. ; Kinsella, B. Therese (Elsevier, 2003-05-02)

In humans, thromboxane (TX) A2 signals through two TXA2 receptor (TP) isoforms, termed TPalpha and TPbeta, that diverge exclusively within their carboxyl terminal cytoplasmic domains. The amino terminal extracellular ...
SCLpred : protein subcellular localization prediction by N-to-1 neural networks

Mooney, Catherine ; Wang, Yong-Hong ; Pollastri, Gianluca (Oxford University Press, 2011-08-27)

Knowledge of the subcellular location of a protein provides valuable information about its function and possible interaction with other proteins. In the post-genomic era, fast and accurate predictors of subcellular location ...
Sirolimus enhances cyclosporine a-induced cytotoxicity in human renal glomerular mesangial cells

O'Connell, Séin ; Slattery, Craig ; Ryan, Michael P. ; McMorrow, Tara (Hindawi, 2012-01-23)

End Stage Renal Disease (ESRD) is an ever increasing problem worldwide. However the mechanisms underlying disease progression are not fully elucidated. This work addressed the nephrotoxicity induced by the immunosuppressive ...
SLiMFinder : a web server to find novel, significantly over-represented, short protein motifs

Davey, Norman E. ; Haslam, Niall J. ; Shields, Denis C. ; Edwards, Richard J. (Oxford University Press, 2010-07)

Short, linear motifs (SLiMs) play a critical role in many biological processes, particularly in protein–protein interactions. The Short, Linear Motif Finder (SLiMFinder) web server is a de novo motif discovery tool that ...
SLiMSearch 2.0 : biological context for short linear motifs in proteins

Davey, Norman E. ; Haslam, Niall J. ; Shields, Denis C. ; Edwards, Richard J. (Oxford University Press, 2011-05-26)

Short, linear motifs (SLiMs) play a critical role in many biological processes. The SLiMSearch 2.0 (Short, Linear Motif Search) web server allows researchers to identify occurrences of a user-defined SLiM in a proteome, ...
SLiMSearch : a webserver for finding novel occurrences of short linear motifs in proteins, incorporating sequence context

Davey, Norman E. ; Haslam, Niall J. ; Shields, Denis C. ; Edwards, Richard J. (Springer, 2010)

Short, linear motifs (SLiMs) play a critical role in many biological processes. The SLiMSearch (Short, Linear Motif Search) webserver is a flexible tool that enables researchers to identify novel occurrences of pre- defined ...
Synthetic peroxisome proliferator-activated receptor gamma agonists rosiglitazone and troglitazone suppress transcription by promoter 3 of the human thromboxane A2 receptor gene in human erythroleukemia cells

Coyle, Adrian T. ; Kinsella, B. Therese (Elsevier, 2006-04-28)

The human thromboxane (TX)A2 receptor (TP) gene encodes two TP isoforms, TPalpha and TP beta that are regulated by distinct promoters designated promoter (Prm) 1 and Prm3, respectively. Previous studies established that ...
Thromboxane A2 receptor mediated activation of the mitogen activated protein kinase cascades in human uterine smooth muscle cells

Miggin, Sinead M. ; Kinsella, B. Therese (Elsevier, 2001-05-28)

Both thromboxane (TX) A2 and 8-epi prostaglandin (PG) F2alpha have been reported to stimulate mitogenesis of vascular smooth muscle (SM) in a number of species. However, TXA2 and 8-epiPGF2alpha mediated mitogenic signalling ...
Thromboxane A2 signalling in humans : a ‘tail’ of two receptors

Kinsella, B. Therese (Portland Press, 2001)

Since its discovery in 1975, we now have a wealth of knowledge relating to the biochemical, pharmacological and physiologic actions of thromboxane (TX) A2 and its related metabolites. These molecular insights have been ...
Towards the Improved Discovery and Design of Functional Peptides: Common Features of Diverse Classes Permit Generalized Prediction of Bioactivity

Mooney, Catherine ; Haslam, Niall J. ; Pollastri, Gianluca ; Shields, Denis C. (PLOS, 2012-10)

The conventional wisdom is that certain classes of bioactive peptides have specific structural features that endow their particular functions. Accordingly, predictions of bioactivity have focused on particular subgroups, ...
Transcriptional regulation of the human prostacyclin receptor gene is dependent on Sp1, PU.1 and Oct-1 in megakaryocytes and endothelial cells

Turner, Elizebeth C. ; Kinsella, B. Therese (Elsevier, 2009-02-27)

Prostacyclin plays a central role in haemostasis, inflammation and nociception. However, the factors regulating expression of the prostacyclin receptor (IP) gene in humans, or in other species, have not been identified. ...
The Wilms’ tumor suppressor protein WT1 acts as a key transcriptional repressor of the human thromboxane A2 receptor gene in megakaryocytes

Gannon, AnneMarie ; Kinsella, B. Therese (Wiley-Blackwell, 2009-11)

In humans, TPα and TPβ isoforms of the thromboxane A2 receptor are transcriptionally regulated by distinct promoters, designated Prm1 and Prm3. Previous investigations identified two upstream repressor regions (URR) 1 and ...