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Browsing Biomolecular and Biomedical Science Research Collection by Title

Browsing Biomolecular and Biomedical Science Research Collection by Title

Now showing items 1-20 of 56

The Addicted Self: A Neuroscientific Perspective

Regan, Ciaran M. (Palgrave Macmillan, 2012-11)
Addiction as a Disease State

Regan, Ciaran M. (2012)
Astrocytes and the regulation of cerebral cysteine/cystine redox potential: implications for cysteine neurotoxicity

McBean, Gethin J. (Nova Publishers, 2012-02-28)

The sulfur amino acid, cysteine plays an essential role in maintaining cellular redox potential and is a key constituent of the antioxidant, glutathione. Cysteine is highly reactive and readily oxidises to the disulfide ...
Bacterial defluorination of 4-fluoroglutamic acid

Donnelly, Clár ; Murphy, Cormac D. (Springer, 2007)

Fluorinated amino acids are used as enzyme inhibitors, mechanistic probes and in the production of pharmacologically active peptides. Because enantiomerically pure 4-fluoroglutamate is difficult to prepare, the selective ...
Bacterial production of hydroxylated and amidated metabolites of flurbiprofen

Bright, Tara V. ; Clark, Benjamin R. ; O'Brien, Eimear ; Murphy, Cormac D. (Elsevier, 2011-11)

Several Streptomyces and Bacillus strains were examined for their ability to transform the anti-inflammatory drug flurbiprofen 1 to the hydroxylated metabolites that are found in humans after ingestion of this compound. ...
Biosynthesis of pyrrolylpolyenes in Auxarthron umbrinum

Clark, Benjamin R. ; Murphy, Cormac D. (RSC Publishing, 2009)

The biosynthesis of the pyrrolylpolyene rumbrin (1) in the fungus Auxarthron umbrinum was elucidated using feeding studies with labelled precursors. Incorporation of stable isotopes from [15N]-proline, [13C]-methionine and ...
Biotransformation of fluorobiphenyl by Cunninghamella elegans

Amadio, Jessica ; Murphy, Cormac D. (Springer, 2010)

The fungus Cunninghamella elegans is a useful model of human catabolism of xenobiotics. In this paper, the biotransformation of fluorinated biphenyls by C. elegans was investigated by analysis of the culture supernatants ...
Biotransformation of flurbiprofen by Cunninghamella species

Amadio, Jessica ; Gordon, Katherine ; Murphy, Cormac D. (American Society for Microbiology, 2010-09)

The biotransformation of the fluorinated anti-inflammatory drug flurbiprofen was investigated in Cunninghamella spp. Mono- and di-hydroxylated metabolites were detected using gas chromatography-mass spectrometry and ...
Characterization of alcohol dehydrogenase (ADH12) from Haloarcula marismortui, an extreme halophile from the Dead Sea

Timpson, Leanne M. ; Alsafadi, Diya ; Mac Donnchadha, Cillin ; Liddell, Susan ; Sharkey, Michael A. ; Paradisi, Francesca (Springer, 2012-01)

Haloarchaeal alcohol dehydrogenases are of increasing interest as biocatalysts in the field of white biotechnology. In this study, the gene adh12 from the extreme halophile Haloarcula marismortui (HmADH12), encoding a 384 ...
Class I histone deacetylase inhibition ameliorates social cognition and cell adhesion molecule plasticity deficits in a rodent model of autism spectrum disorder

Foley, Andrew G. ; Gannon, Shane ; Rombach-Mullan, Nanette ; Prendergast, Alison ; Barry, Claire ; Cassidy, Andrew W. ; Regan, Ciaran M. (Elsevier, 2012-09)

In utero exposure of rodents to valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, has been proposed to induce an adult phenotype with behavioural characteristics reminiscent of those observed in autism spectrum ...
Differential regulation of RhoA-mediated signaling by the TPalpha and TPbeta isoforms of the human thromboxane A2 receptor : independent modulation of TPalpha signaling by prostacyclin and nitric oxide

Wikström, Katarina ; Kavanagh, David J. ; Reid, Helen M. ; Kinsella, B. Therese (Elsevier, 2008-08)

In humans, thromboxane (TX) A2 signals through the TPalpha and TPbeta isoforms of the TXA2 receptor that exhibit common and distinct roles. For example, Gq/phospholipase (PL)Cbeta signaling by TPalpha is directly inhibited ...
Disinfection of meticillin-resistant Staphylococcus aureus and Staphylococcus epidermidis biofilms using a remote non-thermal gas plasma

Cotter, John J. ; Maguire, Paul ; Soberon, Felipe ; Daniels, Stephen ; O'Gara, James P. ; Casey, Eoin (Elsevier, 2011-05)

The effective disinfection of hospital surfaces is recognised as an important factor in preventing hospital-acquired infections. The purpose of this study was to quantify the disinfection rate of a novel gas plasma system ...
Electrostatics in proteins and protein-ligand complexes

Kukić, Predrag ; Nielsen, Jens Erik (2010-04)

Accurate computational methods for predicting the electrostatic energies are of major importance for our understanding of protein energetics in general, for computer-aided drug design and in the design of novel biocatalysts ...
Estrogen increases expression of the human prostacyclin receptor within the vasculature through an ERα-dependent mechanism

Turner, Elizebeth C. ; Kinsella, B. Therese (Elsevier, 2010-02-26)

Prostacyclin and the prostacyclin receptor (IP) are implicated in mediating many of the atheroprotective effects of estrogen in both humans and in animal models but through unknown mechanisms. Hence, herein the influence ...
Examination of cell-host-biomaterial interactions via high-throughput technologies : a re-appraisal

Power, Karen Ann ; Fitzgerald, Kathleen T. ; Gallagher, William M. (Elsevier, 2010-09)

Biomaterials are required to act harmoniously when exposed to the body or bodily fluids. Investigating cellular or in vivo phenotypic responses and protein adsorption to the material surface helps to determine the associated ...
Expression and tissue distribution of the mRNAs encoding the human thromboxane A2 receptor (TP) alpha and beta isoforms

Miggin, Sinead M. ; Kinsella, B. Therese (Elsevier, 1998-11-27)

The human (h) TXA2 receptor (TP), a G protein-coupled receptor, exists as two isoforms, TPalpha and TPbeta, which arise by alternative mRNA splicing and differ exclusively in their carboxyl terminal cytoplasmic regions. ...
Factors influencing 4-fluorobenzoate degradation in biofilm cultures of Pseudomonas knackmussii B13

Misiak, Katarzyna ; Casey, Eoin ; Murphy, Cormac D. (Elsevier, 2011-05)

Membrane aerated biofilm reactors (MABRs) have potential in wastewater treatment as they permit simultaneous COD minimisation, nitrification and denitrification. Here we report on the application of the MABR to the removal ...
The Formation of Medical Expertise

Regan, Ciaran M. (2012)
Homologous desensitization of signalling by the beta isoform of the human thromboxane A2 receptor

Kelley-Hickie, Leanne P. ; Kinsella, B. Therese (Elsevier, 2006-09)

Thromboxane (TX) A2 is a potent stimulator of platelet activation/aggregation and smooth muscle contraction and contributes to a variety of pathologies within the vasculature. In this study, we investigated the mechanism ...
Identification of an interaction between the TPalpha and TPbeta isoforms of the human thromboxane A2 receptor with protein kinase C-related kinase (PRK) 1 : implications for prostate cancer.

Turner, Elizebeth C. ; Kavanagh, David J. ; Mulvaney, Eamon P. ; McLean, Caitriona ; Wikström, Katarina ; Reid, Helen M. ; Kinsella, B. Therese (American Society for Biochemistry and Molecular Biology, 2011-04-29)

In humans, thromboxane (TX)A2 signals through the TPalpha and TPbeta isoforms of the TXA2 receptor, or TP. Herein, the RhoA effector protein kinase C-related kinase (PRK) 1 was identified as an interactant of both TPalpha ...