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Browsing Biomolecular and Biomedical Science Research Collection by Title

Browsing Biomolecular and Biomedical Science Research Collection by Title

Now showing items 43-56 of 56

Recycling of the human prostacyclin receptor is regulated through a direct interaction with Rab11a GTPase

Wikström, Katarina ; Reid, Helen M. ; Hill, Maria ; English, Karol A. ; O'Keeffe, Martina B. ; Kimbembe, Cisca C. ; Kinsella, B. Therese (Elsevier, 2008-12)

The human prostacyclin receptor (hIP) undergoes agonist-induced internalization but the mechanisms regulating its intracellular trafficking and/or recycling to the plasma membrane are poorly understood. Herein, we conducted ...
Regulated expression of the α isoform of the human thromboxane A2 receptor during megakaryocyte differentiation : a coordinated role for WT1, Egr1 & Sp1

Gannon, AnneMarie ; Turner, Elizebeth C. ; Reid, Helen M. ; Kinsella, B. Therese (Elsevier, 2009-11-20)

Thromboxane plays an essential role in haemostasis, regulating platelet aggregation and vessel tone. In humans, it signals through the TPalpha and TPbeta isoforms that are transcriptionally regulated by distinct promoters, ...
Regulation of the Human Prostacyclin Receptor Gene by the Cholesterol-responsive Sterol Response Element Binding Protein (SREBP) 1.

Turner, Elizebeth C. ; Kinsella, B. Therese (American Society for Biochemistry and Molecular Biology, Inc., 2012-09-11)

Prostacyclin and its prostacyclin receptor, the IP, play essential roles in regulating haemostasis and vascular tone and have also been implicated in a range cardio-protective effects, but through largely unknown mechanisms. ...
Regulation of the human prostacyclin receptor gene in megakaryocytes : major roles for C/EBPδ and PU.1

Keating, Garret L. ; Turner, Elizebeth C. ; Kinsella, B. Therese (Elsevier, 2012-05)

The prostanoid prostacyclin plays a central role in haemostasis and vascular repair. Recent studies investigating the regulation of the human prostacyclin receptor (hIP) gene identified an upstream repressor region (URR) ...
Role of Genomics and RNA-seq in Studies of Fungal Virulence

Riccombeni, Alessandro ; Butler, Geraldine (Springer, 2012-09-16)

Since its introduction in the last decade, massive parallel sequencing, or “next-generation sequencing”, has revolutionized our access to genomic information, providing accurate data with increasingly higher yields and ...
The Role of MAPK in Drug-Induced Kidney Injury

Cassidy, Hilary ; Radford, Robert ; Slyne, Jennifer ; O'Connell, Sein ; Slattery, Craig ; Ryan, Michael P. ; McMorrow, Tara (Hindawi Publishers, 2012)

This paper focuses on the role that mitogen-activated protein kinases (MAPKs) play in drug-induced kidney injury. The MAPKs, of which there are four major classes (ERK, p38, JNK, and ERK5/BMK), are signalling cascades ...
The role of N-linked glycosylation in determining the surface expression, G protein interaction and effector coupling of the alpha isoform of the human thromboxane A2 receptor

Kelley-Hickie, Leanne P. ; Kinsella, B. Therese (Elsevier, 2003-05-02)

In humans, thromboxane (TX) A2 signals through two TXA2 receptor (TP) isoforms, termed TPalpha and TPbeta, that diverge exclusively within their carboxyl terminal cytoplasmic domains. The amino terminal extracellular ...
Sirolimus enhances cyclosporine a-induced cytotoxicity in human renal glomerular mesangial cells

O'Connell, Séin ; Slattery, Craig ; Ryan, Michael P. ; McMorrow, Tara (Hindawi, 2012-01-23)

End Stage Renal Disease (ESRD) is an ever increasing problem worldwide. However the mechanisms underlying disease progression are not fully elucidated. This work addressed the nephrotoxicity induced by the immunosuppressive ...
Synthetic peroxisome proliferator-activated receptor gamma agonists rosiglitazone and troglitazone suppress transcription by promoter 3 of the human thromboxane A2 receptor gene in human erythroleukemia cells

Coyle, Adrian T. ; Kinsella, B. Therese (Elsevier, 2006-04-28)

The human thromboxane (TX)A2 receptor (TP) gene encodes two TP isoforms, TPalpha and TP beta that are regulated by distinct promoters designated promoter (Prm) 1 and Prm3, respectively. Previous studies established that ...
Targeting tumour necrosis factor-α in hypoxia and synaptic signalling

O'Connor, J. J. (Springer-Verlag, 2013-01)

Tumour necrosis factor (TNF)-α is a pro-inflammatory cytokine, which is synthesised and released in the brain by astrocytes, microglia and neurons in response to numerous internal and external stimuli. It is involved in ...
Thromboxane A2 receptor mediated activation of the mitogen activated protein kinase cascades in human uterine smooth muscle cells

Miggin, Sinead M. ; Kinsella, B. Therese (Elsevier, 2001-05-28)

Both thromboxane (TX) A2 and 8-epi prostaglandin (PG) F2alpha have been reported to stimulate mitogenesis of vascular smooth muscle (SM) in a number of species. However, TXA2 and 8-epiPGF2alpha mediated mitogenic signalling ...
Thromboxane A2 signalling in humans : a ‘tail’ of two receptors

Kinsella, B. Therese (Portland Press, 2001)

Since its discovery in 1975, we now have a wealth of knowledge relating to the biochemical, pharmacological and physiologic actions of thromboxane (TX) A2 and its related metabolites. These molecular insights have been ...
Transcriptional regulation of the human prostacyclin receptor gene is dependent on Sp1, PU.1 and Oct-1 in megakaryocytes and endothelial cells

Turner, Elizebeth C. ; Kinsella, B. Therese (Elsevier, 2009-02-27)

Prostacyclin plays a central role in haemostasis, inflammation and nociception. However, the factors regulating expression of the prostacyclin receptor (IP) gene in humans, or in other species, have not been identified. ...
The Wilms’ tumor suppressor protein WT1 acts as a key transcriptional repressor of the human thromboxane A2 receptor gene in megakaryocytes

Gannon, AnneMarie ; Kinsella, B. Therese (Wiley-Blackwell, 2009-11)

In humans, TPα and TPβ isoforms of the thromboxane A2 receptor are transcriptionally regulated by distinct promoters, designated Prm1 and Prm3. Previous investigations identified two upstream repressor regions (URR) 1 and ...