Browsing School of Biomolecular & Biomedical Science by Subject "Fluorine"

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Biotransformation of fluorobiphenyl by Cunninghamella elegans

Amadio, Jessica ; Murphy, Cormac D. (Springer, 2010)

The fungus Cunninghamella elegans is a useful model of human catabolism of xenobiotics. In this paper, the biotransformation of fluorinated biphenyls by C. elegans was investigated by analysis of the culture supernatants ...
Biotransformation of flurbiprofen by Cunninghamella species

Amadio, Jessica ; Gordon, Katherine ; Murphy, Cormac D. (American Society for Microbiology, 2010-09)

The biotransformation of the fluorinated anti-inflammatory drug flurbiprofen was investigated in Cunninghamella spp. Mono- and di-hydroxylated metabolites were detected using gas chromatography-mass spectrometry and ...
Precursor-directed biosynthesis of fluorinated iturin A in Bacillus spp.

Moran, Stephen ; Rai, Dilip K. ; Clark, Benjamin R. ; Murphy, Cormac D. (RSC Publishing, 2009)

Some iturin A-producing strains of Bacillus subtilis will elaborate the novel fluorinated analogue when incubated with 3-fluoro-L-tyrosine. The activity of iturin A is dependent on the D-tyrosine residue and the presence ...