Browsing School of Biomolecular & Biomedical Science by Author "Clark, Benjamin R."

DSpace/Manakin Repository

You are here:
Research Repository UCD
>
College of Science
>
School of Biomolecular & Biomedical Science
>
Browsing School of Biomolecular & Biomedical Science by Author

Browsing School of Biomolecular & Biomedical Science by Author "Clark, Benjamin R."

Now showing items 1-5 of 5

Bacterial production of hydroxylated and amidated metabolites of flurbiprofen

Bright, Tara V. ; Clark, Benjamin R. ; O'Brien, Eimear ; Murphy, Cormac D. (Elsevier, 2011-11)

Several Streptomyces and Bacillus strains were examined for their ability to transform the anti-inflammatory drug flurbiprofen 1 to the hydroxylated metabolites that are found in humans after ingestion of this compound. ...
Biosynthesis of pyrrolylpolyenes in Auxarthron umbrinum

Clark, Benjamin R. ; Murphy, Cormac D. (RSC Publishing, 2009)

The biosynthesis of the pyrrolylpolyene rumbrin (1) in the fungus Auxarthron umbrinum was elucidated using feeding studies with labelled precursors. Incorporation of stable isotopes from [15N]-proline, [13C]-methionine and ...
Precursor-directed biosynthesis of fluorinated iturin A in Bacillus spp.

Moran, Stephen ; Rai, Dilip K. ; Clark, Benjamin R. ; Murphy, Cormac D. (RSC Publishing, 2009)

Some iturin A-producing strains of Bacillus subtilis will elaborate the novel fluorinated analogue when incubated with 3-fluoro-L-tyrosine. The activity of iturin A is dependent on the D-tyrosine residue and the presence ...
Production of anticancer polyenes through precursor-directed biosynthesis

Clark, Benjamin R. ; O'Connor, Stephen ; Fox, Deirdre ; Leroy, Jacques ; Murphy, Cormac D. (RSC Publishing, 2011-09)

The biosynthesis of the pyrrolyl moiety of the fungal metabolite rumbrin originates from pyrrole-2-carboxylic acid. In an effort to produce novel derivatives with enhanced biological activity a series of substituted ...
Production of the Novel Lipopeptide Antibiotic Trifluorosurfactin via Precursor-Directed Biosynthesis.

O'Connor, Neil K. ; Rai, Dilip K. ; Clark, Benjamin R. ; Murphy, Cormac D. (Elsevier, 2012-11)

Incorporation of fluorine into antibiotics can moderate their biological activity, lipophilicity and metabolic stability. The introduction of fluorine into an antimicrobial lipopeptide produced by Bacillus sp. CS93 via ...