Browsing College of Science by Author "Rai, Dilip K."

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Precursor-directed biosynthesis of fluorinated iturin A in Bacillus spp.

Moran, Stephen ; Rai, Dilip K. ; Clark, Benjamin R. ; Murphy, Cormac D. (RSC Publishing, 2009)

Some iturin A-producing strains of Bacillus subtilis will elaborate the novel fluorinated analogue when incubated with 3-fluoro-L-tyrosine. The activity of iturin A is dependent on the D-tyrosine residue and the presence ...
Production of the Novel Lipopeptide Antibiotic Trifluorosurfactin via Precursor-Directed Biosynthesis.

O'Connor, Neil K. ; Rai, Dilip K. ; Clark, Benjamin R. ; Murphy, Cormac D. (Elsevier, 2012-11)

Incorporation of fluorine into antibiotics can moderate their biological activity, lipophilicity and metabolic stability. The introduction of fluorine into an antimicrobial lipopeptide produced by Bacillus sp. CS93 via ...