In humans, thromboxane (TX)A2 signals through the TPalpha and TPbeta isoforms of the TXA2 receptor, or TP. Herein, the RhoA effector protein kinase C-related kinase (PRK) 1 was identified as an interactant of both TPalpha ...
The human prostacyclin receptor (hIP) undergoes agonist-dependent trafficking involving a direct interaction with Rab11a GTPase. The region of interaction was localised to a 14 residue Rab11a binding domain (RBD) within ...
The calcineurin inhibitor cyclosporine A (CsA) is a widely used immunosuppressive agent. However,nephrotoxicity is a serious side effect observed in patients which limits clinical use of CsA. CsA nephrotoxicity is associated ...
Chronic allograft nephropathy (CAN) remains the leading cause of renal graft loss after the first year following renal transplantation. This study aimed to identify novel urinary proteomic profiles, which could distinguish ...
Significant payment flows now take place on-line, giving rise to a requirement for efficient and effective systems for the detection of credit card fraud. A particular aspect of this problem is that it is highly dynamic, ...
We apply methods from social network analysis and visualization to facilitate a study of the Irish blogosphere from a cultural studies perspective. We focus on solving the practical issues that arise when the goal is to ...
Networked robotic applications enable robots to operate in distant, hazardous, or otherwise inaccessible environments, such as search and rescue, surveillance, and exploration applications.
The most difficult challenge ...
Upland headwater streams are dynamic systems, responding rapidly to changes in climatic conditions. This study examined the effects of a catastrophic rainfall event, that occured on 24 October 2011 on the east coast of ...
Empirical rock properties and continuum mechanics provide a basis for defining relationships between a variety of mechanical properties, such as strength, friction angle, Young’s modulus, Poisson’s ratio, on the one hand ...
Locality - how well neighbouring genotypes correspond to neighbouring phenotypes - has been described as a key element in Evolutionary Computation. Grammatical Evolution (GE) is a generative system as it uses grammar rules ...
Ambient Exercise refers to the implicit exercise that people undertake in the course of their everyday duties - a simple example being climbing stairs. Increasing awareness of the potential health benefits of such activities ...
Intelligent User Interfaces represent one of the three distinguishing characteristics of AmI environments. Such interfaces are envisaged as mediating between the services available in an arbitrary physical environment and ...
Enabling intuitive interaction in system design remains an art more than a science. This difficulty is exacerbated when the diversity of device and end user group is considered. In this paper, it is argued
that conventional ...
Enabling intuitive interaction in system design remains an art more than a science. This difficulty is exacerbated when the diversity of device and end user group is considered. In this paper, it is argued that conventional ...
This paper examines the impact of semantic control on the ability of Genetic Programming (GP) to generalise via a semantic based crossover operator (Semantic Similarity based Crossover - SSC). The use of validation sets ...
Carbon based materials are attractive for biological applications because of their excellent biocompatibility profile. Porous carbons with high specific surface area are particularly interesting because it is possible in ...
The commonly used Maximum Transfer Unit (MTU) on the Internet has
remained unchanged for many years at around 1500 bytes due mainly to
backward compatibility issues. This is in contrast with link data rate,
which has ...
The temporal response of a biomimetic dye-sensitized solar cell (DSSC) is critically linked to the intensity of the incident light. When a DSSC is partially illuminated and the incoming light is of low intensity, the ...
Na/Al2O3 catalysts are tested in the soot oxidation reaction using O-2 and NO/O-2 as oxidising agents. The activity of the catalysts . varies with oxidising agent and the presence of surface SO42-.. NO(g) increases conversion ...
Accumulation of PrP(Sc), an insoluble and protease-resistant pathogenic isoform of the cellular prion protein (PrP(C)), is a hallmark in prion diseases. Branched polyamines, including PPI (poly(propylene imine)) dendrimers, ...