Millions of users are today posting user-generated content online, expressing their opinions on all manner of goods and services, topics and social affairs. While undoubtedly useful,user-generated content presents consumers ...
Protein kinases (PK) control phosphorylation in eukaryotic cells, and thereby regulate
metabolic pathways, cell cycle progression, apoptosis and transcription.
Consequently there is significant interest in manipulating ...
Short linear motifs in proteins (typically 3–12 residues in length) play key roles in protein–protein interactions by frequently binding specifically to peptide binding domains within interacting proteins. Their tendency ...
Applicants to degree courses in Irish colleges and universities rank up to ten degree courses from a list of over five hundred. These data provide a wealth of
information concerning applicant degree choices. A Dirichlet ...
This paper investigates the effects of early stopping as a method to counteract overfitting in evolutionary data modelling using Genetic Programming. Early stopping has been proposed as a method to avoid model overtraining, ...
4-Dimethylaminopyridine (DMAP)-stabilized palladium nanoparticles with a mean diameter of 3.4 +/- 0.5 mn are prepared from the aqueous phase reduction of Na2PdCl4 using NaBH4 in the presence of DMAP. TEM and UV-vis ...
The preparation of supported and unsupported group II oxide catalysts through oxidation of analogous group II acetates (Mg, Ca and Ba) in the presence and absence of a mesoporous silica material (SBA-15) was analysed using ...
Background:
Data from metabolomic studies are typically complex and high-dimensional. Principal component analysis (PCA) is currently the most widely used statistical technique for analyzing metabolomic data. However, ...
In 1976 Procesi and Schacher developed an Artin–Schreier type theory for central simple algebras with involution and conjectured that in such an algebra a totally positive element is always a sum of hermitian squares. In ...
Effective and efficient information management and knowledge sharing has become an essential part of more and more professional tasks in the Product Development Process. Among the varius Knowledge Management technologies, ...
The biosynthesis of the pyrrolyl moiety of the fungal metabolite rumbrin originates from pyrrole-2-carboxylic acid. In an effort to produce novel derivatives with enhanced biological activity a series of substituted ...
Fungi belonging to the genus Cunninghamella have enzymes similar to those employed by mammals for the detoxification of xenobiotics, thus they are useful as models of mammalian drug metabolism, and as a source for drug ...
Incorporation of fluorine into antibiotics can moderate their biological activity, lipophilicity and metabolic stability. The introduction of fluorine into an antimicrobial lipopeptide produced by Bacillus sp. CS93 via ...
Thromboxane (TX) A2 and prostaglandin (PG) D2 mediate opposing actions in platelets and in vascular and non-vascular smooth muscle. Here, we investigated the effects of stimulation of the PGD2 receptor (DP) on signaling ...
A significant step towards establishing the structure and function of a protein is the prediction of the local conformation of the polypeptide chain. In this article, we present systems for the prediction of three new ...
Despite the success of modern Web search engines, challenges remain when it comes to providing people with access to the right information at the right time. In this paper, we describe how a novel combination of case-based ...
The degradation of fluoroacetate by microorganisms has been established for some time, although only a handful of dehalogenases capable of hydrolyzing the stable C-F bond have been studied. The bacterium Pseudomonas ...
We are living in an age of information overload, where it can be difficult to define which information is relevant and important to the end user at a point in time. In this paper, we introduce a solution to apportioning ...
We report a thorough investigation of a series of isomeric complexes with the general formula trans-(pyridylidene)M(PPh3)2Cl (M = Pd, Ni). For the first time, a systematic comparison of normal, abnormal and remote bonding ...
Horse rider ability has long been measured using horse performance, competition results and visual observation. Scientific methods of measuring rider ability on the flat are emerging such as measuring position angles and ...