Fungi belonging to the genus Cunninghamella have enzymes similar to those employed by mammals for the detoxification of xenobiotics, thus they are useful as models of mammalian drug metabolism, and as a source for drug ...
Incorporation of fluorine into antibiotics can moderate their biological activity, lipophilicity and metabolic stability. The introduction of fluorine into an antimicrobial lipopeptide produced by Bacillus sp. CS93 via ...
Thromboxane (TX) A2 and prostaglandin (PG) D2 mediate opposing actions in platelets and in vascular and non-vascular smooth muscle. Here, we investigated the effects of stimulation of the PGD2 receptor (DP) on signaling ...
A significant step towards establishing the structure and function of a protein is the prediction of the local conformation of the polypeptide chain. In this article, we present systems for the prediction of three new ...
Despite the success of modern Web search engines, challenges remain when it comes to providing people with access to the right information at the right time. In this paper, we describe how a novel combination of case-based ...
The degradation of fluoroacetate by microorganisms has been established for some time, although only a handful of dehalogenases capable of hydrolyzing the stable C-F bond have been studied. The bacterium Pseudomonas ...
We are living in an age of information overload, where it can be difficult to define which information is relevant and important to the end user at a point in time. In this paper, we introduce a solution to apportioning ...
We report a thorough investigation of a series of isomeric complexes with the general formula trans-(pyridylidene)M(PPh3)2Cl (M = Pd, Ni). For the first time, a systematic comparison of normal, abnormal and remote bonding ...
Horse rider ability has long been measured using horse performance, competition results and visual observation. Scientific methods of measuring rider ability on the flat are emerging such as measuring position angles and ...
Interest continues to grow in the possibility of understanding the mechanism(s) of nanoparticle-cell interactions. At present there is little knowledge, and essentially no understanding, of the relevant length and time ...
While it is universally held by computer scientists that conference publications
have a higher status in computer science than in other disciplines there is little quantitative evidence in support of this position. The ...
More than 85% of reported brain traumas are classified clinically as “mild” using GCS; qualitative MRI findings are scarce and provide little correspondence to clinical symptoms. Our goal, therefore, was to establish in-vivo ...
The quaternarized pdppz derivative 1 was shown to bind strongly to DNA with concomitant changes in its ground and excited state photophysical properties. Furthermore, the compound also showed rapid cellular uptake, and ...
The integrated management of both spatial and temporal components of information is crucial in order to extract significant knowledge from datasets concerning phenomena of interest to a large variety of applications. ...
A series of rare earth (RE) (La, Nd, Pr) ceria
zirconia materials were analysed for their soot combustion
activity in air and in NO/O2. The materials were characterised
using DRIFT spectroscopy. In general the presence
of ...
This paper presents an approach to the Mario AI Benchmark problem, using the A* algorithm for navigation, and an evolutionary process combining routines for the reactiveness of the resulting bot. The Grammatical Evolution ...
This work has studied a range of acidic catalysts which have been prepared through the modification of mesoporous silica materials. Specifically we have prepared –SO3H modified materials (in the presence and absence of a ...
Consumers frequently rely on user-generated product reviews to guide purchasing decisions. Given the ever increasing volume of such reviews and variations in review
quality, consumers require assistance to effectively ...
Classic computing systems are characterised by heterogeneity, with its inherent advantages and disadvantages. This
raises a number of difficulties for software engineers. The vision offered by a mix-and-match approach is ...
Sensing, monitoring and actuating systems are expected to play a key role in reducing buildings overall energy consumption. Leveraging sensor systems to support energy efficiency in buildings poses novel research challenges ...