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(Elsevier, 2009-08)The peptide-derived glyoxal inhibitor Z-Ala-Ala-Phe-glyoxal has been shown to be ~10 fold more effective as an inhibitor of subtilisin than Z-Ala-Pro-Phe-glyoxal. Signals at 107.2 p.p.m. and 200.5 p.p.m. are observed for ...
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(Elsevier, 2011-10)The Stromelysin-1 catalytic domain83-247 (SCD) is stable for at least 16 hours at pHs 6.0-8.4. At pHs 5.0 and 9.0 there is exponential irreversible denaturation with half lives of 38 and 68 min respectively. At pHs 4.5 ...
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(Elsevier B.V., 2012-02)The chemical shift of the carboxylate carbon of Z-tryptophan is increased from 179.85 to 182.82 ppm and 182.87 on binding to thermolysin and stromelysin-1 respectively. The chemical shift of Z-phenylalanine is also increased ...
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(Center for Game Theory in Economics, 2005-12-05)This paper considers the allocation of essential patents by a profit maximizing monopoly. Using a model incorporating product differentiation and network externalities we show that fixed fee licences are optimal either ...
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(University College Dublin. School of Economics, 1992-05)Internal and external balance are the twins goals of traditional Keynesian macroeconomic policy. New classical economists question whether either of these are related to welfare, since employment fluctuations may be ...
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(Wiley-Blackwell, 2012-01)Protein kinases (PK) control phosphorylation in eukaryotic cells, and thereby regulate metabolic pathways, cell cycle progression, apoptosis and transcription. Consequently there is significant interest in manipulating ...
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(2005-05)A systematic assessment scheme for determining the alkali reactivity of aggregates has been developed for international use. Expansion tests were conducted on Irish aggregates. Aggregates were subjected to a sequence of ...
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(Routledge, 2007-03)This article uses duration analysis to investigate the role of tobacco taxes in starting and quitting smoking. Applying a variety of parametric duration models to a sample of Irish women, it finds that in general tobacco ...
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(Economic and Social Research Institute, 2003)This paper uses duration analysis to investigate the role of tobacco taxes in starting and quitting smoking. Applying a variety of parametric duration models, including a split population model, to a sample of Irish women, ...
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(University College Dublin. School of Economics, 1992)Due primarily to transport improvements, commodity prices in Britain and America tended to equalize 1870-1913. This commodity price equalization was not simply manifested by the great New World grain invasion of Europe. ...