A major challenge in oral drug delivery is the development of novel dosage forms to promote absorption of poorly permeable Class III drugs across the intestinal epithelium.
To date, no absorption promoter has been approved ...
Sodium caprate (C10) is an oral absorption promoter that is currently in clinical trials as a component of solid dosage forms for poorly permeable small molecules and peptides. Clinical data with zoledronic acid tablets ...
A simple and efficient one-step procedure is described for the synthesis of a number of symmetrical 1,4-disubstituted piperazine-2,5-diones under phase transfer conditions. The reactions are carried out at
room temperature, ...
Rare 4-methylenecyclohex-2-enone is prepared from a Diels-Alder methanesulfonate adduct and sodium iodide in acetone in up to 70% yield under mild conditions. This procedure is envisaged to be relevant to the synthesis of ...
One of the key predictions of the nonlocal photopolymerization driven diffusion (NPDD) model is that a reduction in the extent of the nonlocal effects within a material will improve the high spatial frequency response.
The ...
Intensive monitoring has been carried out under EC Regulation 3528/86 (project number
8860 IR 001.0) at Ballyhooly, Co. Cork since 1988. In 1991, three new plots (Roundwood, Cloosh and Brackloon) were established (9060IR0030) ...