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(Karger, 2010-11-24)Background: High mobility group box protein 1 (HMGB-1) is a chromatin binding protein that bends DNA thereby facilitating gene transcription. HMGB-1 has also been observed as an extracellular secreted protein in serum of ...
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(Elsevier, 2010-04)Persistent inflammation underlies many of the most prevalent diseases in the developed world including atherosclerosis and diabetes. There is a growing appreciation that inflammation and its active resolution may be ...
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(2010-04)Cystic Fibrosis (CF) is the most common life-limiting genetic disease in caucasians. Skeletal muscle weakness and exercise intolerance is prevalent in people with cystic fibrosis. Although higher levels of fitness have ...
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(2010-04)Cystic Fibrosis (CF) is the most common life-limiting genetic disease in Caucasians. [1] Progressive respiratory and gastro intestinal disease are the predominant clinical manifestations of the disease. As a consequence ...
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(Intech, 2012)The first successful transplantation of a human kidney was performed more than 50 years ago by Murray and colleagues in 1954 between identical twins. The success of this transplantation was due to the fact that no significant ...
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(Wiley, 2011-08)Chronic allograft nephropathy (CAN) remains the leading cause of renal graft loss after the first year following renal transplantation. This study aimed to identify novel urinary proteomic profiles, which could distinguish ...
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(Hindawi, 2012-01-23)End Stage Renal Disease (ESRD) is an ever increasing problem worldwide. However the mechanisms underlying disease progression are not fully elucidated. This work addressed the nephrotoxicity induced by the immunosuppressive ...
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(Elsevier, 2011-04-15)The calcineurin inhibitor cyclosporine A (CsA) is a widely used immunosuppressive agent. However,nephrotoxicity is a serious side effect observed in patients which limits clinical use of CsA. CsA nephrotoxicity is associated ...
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(Nature Publishing Group, 2011-10)Primary vesicoureteral reflux (VUR) is the most common urological anomaly in children, affecting 1–2% of the pediatric population and 30–40% of children presenting with urinary tract infections (UTIs). Refluxassociated ...
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(Wiley, 2010-08)This paper describes the development, in an Irish context, of a 3-factor, 28-item version the Systemic Clinical Outcome and Routine Evaluation (SCORE) questionnaire for assessing progress in family therapy. The 40-item ...