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PK/PD modelling of combed-shaped PEGylated salmon calcitonin conjugates of differing molecular weights

Ryan, Sinead M. ; Frías, Jesús M. ; Wang, Xuexuan ; Sayers, Claire T. ; Haddleton, David M. ; Brayden, David James (Elsevier, 2011-01-20)

Salmon calcitonin (sCT) was conjugated via cysteine-1 to novel comb-shaped end-functionalised (poly(PEG) methyl ether methacrylate) (sCT-P) polymers, to yield conjugates of total molecular weights (MW) inclusive of sCT: ...
Colonic absorption of salmon calcitonin using tetradecyl maltoside (TDM) as a permeation enhancer

Petersen, Signe Beck ; Nielsen, Lisette Gammelgaard ; Rahbek, Ulrik Lytt ; Guldbrandt, Mette ; Brayden, David James (Elsevier, 2013-03)

Calcitonin is used as a second line treatment of postmenopausal osteoporosis, but widespread acceptance is somewhat limited by subcutaneous and intranasal routes of delivery. This study attempted to enable intestinal sCT ...

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