The fungus Cunninghamella elegans is a useful model of human catabolism of xenobiotics. In this paper, the biotransformation of fluorinated biphenyls by C. elegans was investigated by analysis of the culture supernatants ...
The biotransformation of the fluorinated anti-inflammatory drug flurbiprofen was investigated in Cunninghamella spp. Mono- and di-hydroxylated metabolites were detected using gas chromatography-mass spectrometry and ...
Fungi belonging to the genus Cunninghamella have enzymes similar to those employed by mammals for the detoxification of xenobiotics, thus they are useful as models of mammalian drug metabolism, and as a source for drug ...
Neuromuscular fatigue is believed to be a contributing factor to injury in athletic situations. To examine this idea, it is necessary to establish functional fatigue models that are representative of the type of physical ...
Chronic obstructive pulmonary disease (COPD) patients commonly find it difficult to participate in conventional aerobic exercise training owing to limited cardiopulmonary reserve, excessive dyspnoea and muscle fatigue. ...
Protein kinases (PK) control phosphorylation in eukaryotic cells, and thereby regulate
metabolic pathways, cell cycle progression, apoptosis and transcription.
Consequently there is significant interest in manipulating ...
Fluorinated organic compounds have widespread applications, and their accumulation in the environment is a concern. Biofilm reactors are an effective technology for the treatment of contaminated wastewater, yet almost no ...
Comparisons between the physiological properties of Pseudomonas fluorescens biofilm cells grown in a tubular biofilm reactor and planktonic cells grown in a chemostat were performed. Fluoroacetate was the sole carbon source ...
Background:
Data from metabolomic studies are typically complex and high-dimensional. Principal component analysis (PCA) is currently the most widely used statistical technique for analyzing metabolomic data. However, ...