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Thromboxane A2 receptor mediated activation of the mitogen activated protein kinase cascades in human uterine smooth muscle cells

Miggin, Sinead M. ; Kinsella, B. Therese (Elsevier, 2001-05-28)

Both thromboxane (TX) A2 and 8-epi prostaglandin (PG) F2alpha have been reported to stimulate mitogenesis of vascular smooth muscle (SM) in a number of species. However, TXA2 and 8-epiPGF2alpha mediated mitogenic signalling ...
The Role of MAPK in Drug-Induced Kidney Injury

Cassidy, Hilary ; Radford, Robert ; Slyne, Jennifer ; O'Connell, Sein ; Slattery, Craig ; Ryan, Michael P. ; McMorrow, Tara (Hindawi Publishers, 2012)

This paper focuses on the role that mitogen-activated protein kinases (MAPKs) play in drug-induced kidney injury. The MAPKs, of which there are four major classes (ERK, p38, JNK, and ERK5/BMK), are signalling cascades ...
Sirolimus enhances cyclosporine a-induced cytotoxicity in human renal glomerular mesangial cells

O'Connell, Séin ; Slattery, Craig ; Ryan, Michael P. ; McMorrow, Tara (Hindawi, 2012-01-23)

End Stage Renal Disease (ESRD) is an ever increasing problem worldwide. However the mechanisms underlying disease progression are not fully elucidated. This work addressed the nephrotoxicity induced by the immunosuppressive ...

Now showing items 1-3 of 3