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One-step diketopiperazine synthesis using phase transfer catalysis

O'Reilly, Elaine ; Lestini, Elena ; Balducci, Daniele ; Paradisi, Francesca (Elsevier, 2009-04-15)

A simple and efficient one-step procedure is described for the synthesis of a number of symmetrical 1,4-disubstituted piperazine-2,5-diones under phase transfer conditions. The reactions are carried out at room temperature, ...
From amines to diketopiperazines: a one-pot approach

O'Reilly, Elaine ; Pes, Lara ; Paradisi, Francesca (Elsevier, 2010-03-31)

An efficient one-pot synthesis is described for the preparation of 1,4-disubstituted piperazine-2,5-diones starting from a suitable amine and chloroacetyl chloride in the presence of an aqueous base. The resulting chlo ...
A stereoselective synthesis of α-deuterium labelled (S)-α-amino acids

O'Reilly, Elaine ; Balducci, Daniele ; Paradisi, Francesca (Springer, 2010)

An atom-efficient and stereoselective synthesis has been developed for the preparation of a-2H-labelled(S)-a-amino acids, starting from a novel chiral diketopiperazine scaffold. Efficient mono-alkylation of the chiral ...

Now showing items 1-3 of 3