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Oxyanion and tetrahedral intermediate stabilization by subtilisin : detection of a new tetrahedral adduct

Howe, Nicole ; Rogers, Louis ; Hewage, Chandralal ; Malthouse, J.Paul G. (Elsevier, 2009-08)

The peptide-derived glyoxal inhibitor Z-Ala-Ala-Phe-glyoxal has been shown to be ~10 fold more effective as an inhibitor of subtilisin than Z-Ala-Pro-Phe-glyoxal. Signals at 107.2 p.p.m. and 200.5 p.p.m. are observed for ...
PK/PD modelling of combed-shaped PEGylated salmon calcitonin conjugates of differing molecular weights

Ryan, Sinead M. ; Frías, Jesús M. ; Wang, Xuexuan ; Sayers, Claire T. ; Haddleton, David M. ; Brayden, David James (Elsevier, 2011-01-20)

Salmon calcitonin (sCT) was conjugated via cysteine-1 to novel comb-shaped end-functionalised (poly(PEG) methyl ether methacrylate) (sCT-P) polymers, to yield conjugates of total molecular weights (MW) inclusive of sCT: ...

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