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Towards the Improved Discovery and Design of Functional Peptides: Common Features of Diverse Classes Permit Generalized Prediction of Bioactivity

Mooney, Catherine ; Haslam, Niall J. ; Pollastri, Gianluca ; Shields, Denis C. (PLOS, 2012-10)

The conventional wisdom is that certain classes of bioactive peptides have specific structural features that endow their particular functions. Accordingly, predictions of bioactivity have focused on particular subgroups, ...
Alternative mild route to the synthesis of 4-methylenecyclohex-2-enone, a key moiety of the anticancer compounds ottelione A and B

Lestini, Elena ; Robertson, Keith ; Murphy, Cormac D. ; Paradisi, Francesca (Taylor & Francis, 2012-02-27)

Rare 4-methylenecyclohex-2-enone is prepared from a Diels-Alder methanesulfonate adduct and sodium iodide in acetone in up to 70% yield under mild conditions. This procedure is envisaged to be relevant to the synthesis of ...
PK/PD modelling of combed-shaped PEGylated salmon calcitonin conjugates of differing molecular weights

Ryan, Sinead M. ; Frías, Jesús M. ; Wang, Xuexuan ; Sayers, Claire T. ; Haddleton, David M. ; Brayden, David James (Elsevier, 2011-01-20)

Salmon calcitonin (sCT) was conjugated via cysteine-1 to novel comb-shaped end-functionalised (poly(PEG) methyl ether methacrylate) (sCT-P) polymers, to yield conjugates of total molecular weights (MW) inclusive of sCT: ...

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