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Browsing by Author "Paradisi, Francesca"

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Alternative mild route to the synthesis of 4-methylenecyclohex-2-enone, a key moiety of the anticancer compounds ottelione A and B

Lestini, Elena ; Robertson, Keith ; Murphy, Cormac D. ; Paradisi, Francesca (Taylor & Francis, 2012-02-27)

Rare 4-methylenecyclohex-2-enone is prepared from a Diels-Alder methanesulfonate adduct and sodium iodide in acetone in up to 70% yield under mild conditions. This procedure is envisaged to be relevant to the synthesis of ...
Characterization of alcohol dehydrogenase (ADH12) from Haloarcula marismortui, an extreme halophile from the Dead Sea

Timpson, Leanne M. ; Alsafadi, Diya ; Mac Donnchadha, Cillin ; Liddell, Susan ; Sharkey, Michael A. ; Paradisi, Francesca (Springer, 2012-01)

Haloarchaeal alcohol dehydrogenases are of increasing interest as biocatalysts in the field of white biotechnology. In this study, the gene adh12 from the extreme halophile Haloarcula marismortui (HmADH12), encoding a 384 ...
A comparison of two novel alcohol dehydrogenase enzymes (ADH1 and ADH2) from the extreme halophile Haloferax volcanii

Timpson, Leanne M. ; Liliensiek, Ann-Kathrin ; Alsafadi, Diya ; Cassidy, Jennifer ; Sharkey, Michael A. ; Liddell, Susan ; Allers, Thorsten ; Paradisi, Francesca (Springer, 2013-01)

Haloarchaeal alcohol dehydrogenases are exciting biocatalysts with potential industrial applications. In this study, two alcohol dehydrogenase enzymes from the extremely halophilic archaeon Haloferax volcanii (HvADH1 and ...
Effect of organic solvents on the activity and stability of halophilic alcohol dehydrogenase (ADH2) from Haloferax volcanii

Alsafadi, Diya ; Paradisi, Francesca (Springer, 2013-01-01)

The effect of various organic solvents on the catalytic activity, stability and substrate specificity of alchohol dehydrogenase from Haloferax volcanii (HvADH2) was evaluated. The HvADH2 showed remarkable stability and ...
From amines to diketopiperazines: a one-pot approach

O'Reilly, Elaine ; Pes, Lara ; Paradisi, Francesca (Elsevier, 2010-03-31)

An efficient one-pot synthesis is described for the preparation of 1,4-disubstituted piperazine-2,5-diones starting from a suitable amine and chloroacetyl chloride in the presence of an aqueous base. The resulting chlo ...
Horse Liver Alcohol Dehydrogenase: new perspectives for an old enzyme

Quaglia, Daniela ; Irwin, Jane A. ; Paradisi, Francesca (Springer Science+Business Media, 2012-11)

The EE subunit of horse liver alcohol dehydrogenase (HLADH-EE) has been subcloned in pRSETb vector to generate a fusion His-tag protein. The migration from a multistep purification protocol for this well-known enzyme to ...
Isolation and Characterization of Recovered Starch from Industrial Wastewater

Devereux, Sabrina ; Shuttleworth, Peter ; Macquarrie, Duncan ; Paradisi, Francesca (Springer, 2011)

The wastewater generated at a facility specialising in potato processing was found to contain high levels of insoluble potato starch. Several separation methods were employed to obtain maximum potato starch recovery from ...
Novel approach to the synthesis of aliphatic and aromatic alpha-keto acids

Balducci, Daniele ; Conway, Philip A. ; Sapuppo, Giulia ; Müller-Bunz, Helge ; Paradisi, Francesca (Elsevier, 2012-09)

A new practical and efficient synthesis of alpha-keto acids was accomplished starting from the synthon 1,4-diacetylpiperazine-2,5-dione. The synthesis encompasses both aromatic and aliphatic substrates proving to be versatile ...
One-step diketopiperazine synthesis using phase transfer catalysis

O'Reilly, Elaine ; Lestini, Elena ; Balducci, Daniele ; Paradisi, Francesca (Elsevier, 2009-04-15)

A simple and efficient one-step procedure is described for the synthesis of a number of symmetrical 1,4-disubstituted piperazine-2,5-diones under phase transfer conditions. The reactions are carried out at room temperature, ...
A simple and efficient method for the synthesis of Erlenmeyer azlactones

Conway, Philip A. ; Devine, Kevin ; Paradisi, Francesca (Elsevier, 2009-04-11)

We have recently developed a novel and efficient method for synthesising Erlenmeyer azlactones under mild and rapid conditions. The reaction is performed by reacting 2-phenyl-5-oxazolone with an aldehyde in dichloromethane ...
A stereoselective synthesis of α-deuterium labelled (S)-α-amino acids

O'Reilly, Elaine ; Balducci, Daniele ; Paradisi, Francesca (Springer, 2010)

An atom-efficient and stereoselective synthesis has been developed for the preparation of a-2H-labelled(S)-a-amino acids, starting from a novel chiral diketopiperazine scaffold. Efficient mono-alkylation of the chiral ...
Synthesis of a conformationally constrained delta-amino acid building block

O'Reilly, Elaine ; Pes, Lara ; Ortin, Yannick ; Mueller-Bunz, Helge ; Paradisi, Francesca (Springer, 2013-02)

Conformationally restricted amino acids are important components in peptidomimetics and drug design. Herein, we describe the synthesis of a novel, non-proteinogenic constrained delta amino acid containing a cyclobutane ...