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Browsing by Subject "Transcription factors"

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Estrogen increases expression of the human prostacyclin receptor within the vasculature through an ERα-dependent mechanism

Turner, Elizebeth C. ; Kinsella, B. Therese (Elsevier, 2010-02-26)

Prostacyclin and the prostacyclin receptor (IP) are implicated in mediating many of the atheroprotective effects of estrogen in both humans and in animal models but through unknown mechanisms. Hence, herein the influence ...
Regulation of the Human Prostacyclin Receptor Gene by the Cholesterol-responsive Sterol Response Element Binding Protein (SREBP) 1.

Turner, Elizebeth C. ; Kinsella, B. Therese (American Society for Biochemistry and Molecular Biology, Inc., 2012-09-11)

Prostacyclin and its prostacyclin receptor, the IP, play essential roles in regulating haemostasis and vascular tone and have also been implicated in a range cardio-protective effects, but through largely unknown mechanisms. ...
Regulation of the human prostacyclin receptor gene in megakaryocytes : major roles for C/EBPδ and PU.1

Keating, Garret L. ; Turner, Elizebeth C. ; Kinsella, B. Therese (Elsevier, 2012-05)

The prostanoid prostacyclin plays a central role in haemostasis and vascular repair. Recent studies investigating the regulation of the human prostacyclin receptor (hIP) gene identified an upstream repressor region (URR) ...
Transcriptional regulation of the human prostacyclin receptor gene is dependent on Sp1, PU.1 and Oct-1 in megakaryocytes and endothelial cells

Turner, Elizebeth C. ; Kinsella, B. Therese (Elsevier, 2009-02-27)

Prostacyclin plays a central role in haemostasis, inflammation and nociception. However, the factors regulating expression of the prostacyclin receptor (IP) gene in humans, or in other species, have not been identified. ...
The Wilms’ tumor suppressor protein WT1 acts as a key transcriptional repressor of the human thromboxane A2 receptor gene in megakaryocytes

Gannon, AnneMarie ; Kinsella, B. Therese (Wiley-Blackwell, 2009-11)

In humans, TPα and TPβ isoforms of the thromboxane A2 receptor are transcriptionally regulated by distinct promoters, designated Prm1 and Prm3. Previous investigations identified two upstream repressor regions (URR) 1 and ...