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Browsing by Subject "Protein-protein interactions"

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Interaction of the human prostacyclin receptor with the PDZ adapter protein PDZK : role in endothelial cell migration and angiogenesis

Turner, Elizebeth C. ; Mulvaney, Eamon P. ; Reid, Helen M. ; Kinsella, B. Therese (American Society for Cell Biology, 2011-06-08)

Prostacyclin is increasingly implicated in re-endothelialization and angiogenesis but through largely unknown mechanisms. Herein, the HDL scavenger receptor class B, type 1 (SR-B1) adapter protein PDZ domain-containing ...
Prediction of short linear protein binding regions

Mooney, Catherine ; Pollastri, Gianluca ; Shields, Denis C. ; Haslam, Niall J. (Elsevier, 2012-01-06)

Short linear motifs in proteins (typically 3–12 residues in length) play key roles in protein–protein interactions by frequently binding specifically to peptide binding domains within interacting proteins. Their tendency ...
Profile-based short linear protein motif discovery

Haslam, Niall J. ; Shields, Denis C. (BioMed Central Ltd, 2012-05-18)

Background: Short linear protein motifs are attracting increasing attention as functionally independent sites, typically 3-10 amino acids in length that are enriched in disordered regions of proteins. Multiple methods have ...
Profile-based short linear protein motif discovery.

Haslam, Niall J. ; Shields, Denis C. (BioMed Central, 2012-05-18)

Background Short linear protein motifs are attracting increasing attention as functionally independent sites, typically 3-10 amino acids in length that are enriched in disordered regions of proteins. Multiple methods ...
Recycling of the human prostacyclin receptor is regulated through a direct interaction with Rab11a GTPase

Wikström, Katarina ; Reid, Helen M. ; Hill, Maria ; English, Karol A. ; O'Keeffe, Martina B. ; Kimbembe, Cisca C. ; Kinsella, B. Therese (Elsevier, 2008-12)

The human prostacyclin receptor (hIP) undergoes agonist-induced internalization but the mechanisms regulating its intracellular trafficking and/or recycling to the plasma membrane are poorly understood. Herein, we conducted ...
The role of N-linked glycosylation in determining the surface expression, G protein interaction and effector coupling of the alpha isoform of the human thromboxane A2 receptor

Kelley-Hickie, Leanne P. ; Kinsella, B. Therese (Elsevier, 2003-05-02)

In humans, thromboxane (TX) A2 signals through two TXA2 receptor (TP) isoforms, termed TPalpha and TPbeta, that diverge exclusively within their carboxyl terminal cytoplasmic domains. The amino terminal extracellular ...
SLiMFinder : a web server to find novel, significantly over-represented, short protein motifs

Davey, Norman E. ; Haslam, Niall J. ; Shields, Denis C. ; Edwards, Richard J. (Oxford University Press, 2010-07)

Short, linear motifs (SLiMs) play a critical role in many biological processes, particularly in protein–protein interactions. The Short, Linear Motif Finder (SLiMFinder) web server is a de novo motif discovery tool that ...
SLiMSearch 2.0 : biological context for short linear motifs in proteins

Davey, Norman E. ; Haslam, Niall J. ; Shields, Denis C. ; Edwards, Richard J. (Oxford University Press, 2011-05-26)

Short, linear motifs (SLiMs) play a critical role in many biological processes. The SLiMSearch 2.0 (Short, Linear Motif Search) web server allows researchers to identify occurrences of a user-defined SLiM in a proteome, ...
SLiMSearch : a webserver for finding novel occurrences of short linear motifs in proteins, incorporating sequence context

Davey, Norman E. ; Haslam, Niall J. ; Shields, Denis C. ; Edwards, Richard J. (Springer, 2010)

Short, linear motifs (SLiMs) play a critical role in many biological processes. The SLiMSearch (Short, Linear Motif Search) webserver is a flexible tool that enables researchers to identify novel occurrences of pre- defined ...