An efficient one-pot synthesis is described for the preparation of 1,4-disubstituted piperazine-2,5-diones
starting from a suitable amine and chloroacetyl chloride in the presence of an aqueous base. The resulting
chlo ...
A simple and efficient one-step procedure is described for the synthesis of a number of symmetrical 1,4-disubstituted piperazine-2,5-diones under phase transfer conditions. The reactions are carried out at
room temperature, ...
An atom-efficient and stereoselective synthesis has been developed for the preparation of a-2H-labelled(S)-a-amino acids, starting from a novel chiral diketopiperazine scaffold. Efficient mono-alkylation of the chiral ...
Conformationally restricted amino acids are important components in peptidomimetics and drug design. Herein, we describe the synthesis of a novel, non-proteinogenic constrained delta amino acid containing a cyclobutane ...
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