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Browsing by Author "Kinsella, B. Therese"

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Differential regulation of RhoA-mediated signaling by the TPalpha and TPbeta isoforms of the human thromboxane A2 receptor : independent modulation of TPalpha signaling by prostacyclin and nitric oxide

Wikström, Katarina ; Kavanagh, David J. ; Reid, Helen M. ; Kinsella, B. Therese (Elsevier, 2008-08)

In humans, thromboxane (TX) A2 signals through the TPalpha and TPbeta isoforms of the TXA2 receptor that exhibit common and distinct roles. For example, Gq/phospholipase (PL)Cbeta signaling by TPalpha is directly inhibited ...
Estrogen increases expression of the human prostacyclin receptor within the vasculature through an ERα-dependent mechanism

Turner, Elizebeth C. ; Kinsella, B. Therese (Elsevier, 2010-02-26)

Prostacyclin and the prostacyclin receptor (IP) are implicated in mediating many of the atheroprotective effects of estrogen in both humans and in animal models but through unknown mechanisms. Hence, herein the influence ...
Expression and tissue distribution of the mRNAs encoding the human thromboxane A2 receptor (TP) alpha and beta isoforms

Miggin, Sinead M. ; Kinsella, B. Therese (Elsevier, 1998-11-27)

The human (h) TXA2 receptor (TP), a G protein-coupled receptor, exists as two isoforms, TPalpha and TPbeta, which arise by alternative mRNA splicing and differ exclusively in their carboxyl terminal cytoplasmic regions. ...
Homologous desensitization of signalling by the beta isoform of the human thromboxane A2 receptor

Kelley-Hickie, Leanne P. ; Kinsella, B. Therese (Elsevier, 2006-09)

Thromboxane (TX) A2 is a potent stimulator of platelet activation/aggregation and smooth muscle contraction and contributes to a variety of pathologies within the vasculature. In this study, we investigated the mechanism ...
Identification of an interaction between the TPalpha and TPbeta isoforms of the human thromboxane A2 receptor with protein kinase C-related kinase (PRK) 1 : implications for prostate cancer.

Turner, Elizebeth C. ; Kavanagh, David J. ; Mulvaney, Eamon P. ; McLean, Caitriona ; Wikström, Katarina ; Reid, Helen M. ; Kinsella, B. Therese (American Society for Biochemistry and Molecular Biology, 2011-04-29)

In humans, thromboxane (TX)A2 signals through the TPalpha and TPbeta isoforms of the TXA2 receptor, or TP. Herein, the RhoA effector protein kinase C-related kinase (PRK) 1 was identified as an interactant of both TPalpha ...
Identification of a novel endoplasmic reticulum export motif within the eighth alpha-helical domain (alpha-H8) of the human prostacyclin receptor

Donnellan, Peter D. ; Kimbembe, Cisca C. ; Reid, Helen M. ; Kinsella, B. Therese (Elsevier, 2011-04)

The human prostacyclin receptor (hIP) undergoes agonist-dependent trafficking involving a direct interaction with Rab11a GTPase. The region of interaction was localised to a 14 residue Rab11a binding domain (RBD) within ...
Interaction of angio-associated migratory cell protein with the TPα and TPβ isoforms of the human thromboxane A2 receptor

Reid, Helen M. ; Wikström, Katarina ; Kavanagh, David J. ; Mulvaney, Eamon P. ; Kinsella, B. Therese (Elsevier, 2011-04)

In humans, thromboxane (TX) A2 signals through the TPα and TPβ isoforms of its G-protein coupled TXA2 receptor (TP) to mediate a host of (patho)physiologic responses. Herein, angio-associated migratory cell protein (AAMP) ...
Interaction of the Human Prostacyclin Receptor and the NHERF4 Family member Intestinal and Kidney Enriched PDZ Protein (IKEPP)

Reid, Helen M. ; Turner, Elizebeth C. ; Mulvaney, Eamon P. ; Hyland, Paula B. ; McLean, Caitriona ; Kinsella, B. Therese (Elsevier, 2012-10)

Prostacyclin and its I Prostanoid receptor, the IP, play central roles in haemostasis and in re-endothelialization in response to vascular injury. Herein, Intestinal and Kidney Enriched PDZ Protein (IKEPP) was identified ...
Interaction of the human prostacyclin receptor with the PDZ adapter protein PDZK : role in endothelial cell migration and angiogenesis

Turner, Elizebeth C. ; Mulvaney, Eamon P. ; Reid, Helen M. ; Kinsella, B. Therese (American Society for Cell Biology, 2011-06-08)

Prostacyclin is increasingly implicated in re-endothelialization and angiogenesis but through largely unknown mechanisms. Herein, the HDL scavenger receptor class B, type 1 (SR-B1) adapter protein PDZ domain-containing ...
Investigation of the role of the carboxyl terminal tails of the alpha and beta isoforms of the human thromboxane A2 receptor (TP) in mediating receptor : effector coupling

Walsh, Marie-Therese ; Foley, John F. ; Kinsella, B. Therese (Elsevier, 2000-04-17)

We have investigated the functional coupling of alpha and beta isoforms of the human thromboxane A2 receptor (TP) to Galpha16 and Galpha12 members of the Gq and G12 families of heterotrimeric G proteins in human embryonic ...
Prostaglandin D2 receptor-mediated desensitization of the alpha isoform of the human thromboxane A2 receptor

Foley, John F. ; Kelley-Hickie, Leanne P. ; Kinsella, B. Therese (Elsevier, 2001-07-15)

Thromboxane (TX) A2 and prostaglandin (PG) D2 mediate opposing actions in platelets and in vascular and non-vascular smooth muscle. Here, we investigated the effects of stimulation of the PGD2 receptor (DP) on signaling ...
Recycling of the human prostacyclin receptor is regulated through a direct interaction with Rab11a GTPase

Wikström, Katarina ; Reid, Helen M. ; Hill, Maria ; English, Karol A. ; O'Keeffe, Martina B. ; Kimbembe, Cisca C. ; Kinsella, B. Therese (Elsevier, 2008-12)

The human prostacyclin receptor (hIP) undergoes agonist-induced internalization but the mechanisms regulating its intracellular trafficking and/or recycling to the plasma membrane are poorly understood. Herein, we conducted ...
Regulated expression of the α isoform of the human thromboxane A2 receptor during megakaryocyte differentiation : a coordinated role for WT1, Egr1 & Sp1

Gannon, AnneMarie ; Turner, Elizebeth C. ; Reid, Helen M. ; Kinsella, B. Therese (Elsevier, 2009-11-20)

Thromboxane plays an essential role in haemostasis, regulating platelet aggregation and vessel tone. In humans, it signals through the TPalpha and TPbeta isoforms that are transcriptionally regulated by distinct promoters, ...
Regulation of the Human Prostacyclin Receptor Gene by the Cholesterol-responsive Sterol Response Element Binding Protein (SREBP) 1.

Turner, Elizebeth C. ; Kinsella, B. Therese (American Society for Biochemistry and Molecular Biology, Inc., 2012-09-11)

Prostacyclin and its prostacyclin receptor, the IP, play essential roles in regulating haemostasis and vascular tone and have also been implicated in a range cardio-protective effects, but through largely unknown mechanisms. ...
Regulation of the human prostacyclin receptor gene in megakaryocytes : major roles for C/EBPδ and PU.1

Keating, Garret L. ; Turner, Elizebeth C. ; Kinsella, B. Therese (Elsevier, 2012-05)

The prostanoid prostacyclin plays a central role in haemostasis and vascular repair. Recent studies investigating the regulation of the human prostacyclin receptor (hIP) gene identified an upstream repressor region (URR) ...
The role of N-linked glycosylation in determining the surface expression, G protein interaction and effector coupling of the alpha isoform of the human thromboxane A2 receptor

Kelley-Hickie, Leanne P. ; Kinsella, B. Therese (Elsevier, 2003-05-02)

In humans, thromboxane (TX) A2 signals through two TXA2 receptor (TP) isoforms, termed TPalpha and TPbeta, that diverge exclusively within their carboxyl terminal cytoplasmic domains. The amino terminal extracellular ...
Synthetic peroxisome proliferator-activated receptor gamma agonists rosiglitazone and troglitazone suppress transcription by promoter 3 of the human thromboxane A2 receptor gene in human erythroleukemia cells

Coyle, Adrian T. ; Kinsella, B. Therese (Elsevier, 2006-04-28)

The human thromboxane (TX)A2 receptor (TP) gene encodes two TP isoforms, TPalpha and TP beta that are regulated by distinct promoters designated promoter (Prm) 1 and Prm3, respectively. Previous studies established that ...
Thromboxane A2 receptor mediated activation of the mitogen activated protein kinase cascades in human uterine smooth muscle cells

Miggin, Sinead M. ; Kinsella, B. Therese (Elsevier, 2001-05-28)

Both thromboxane (TX) A2 and 8-epi prostaglandin (PG) F2alpha have been reported to stimulate mitogenesis of vascular smooth muscle (SM) in a number of species. However, TXA2 and 8-epiPGF2alpha mediated mitogenic signalling ...
Thromboxane A2 signalling in humans : a ‘tail’ of two receptors

Kinsella, B. Therese (Portland Press, 2001)

Since its discovery in 1975, we now have a wealth of knowledge relating to the biochemical, pharmacological and physiologic actions of thromboxane (TX) A2 and its related metabolites. These molecular insights have been ...
Transcriptional regulation of the human prostacyclin receptor gene is dependent on Sp1, PU.1 and Oct-1 in megakaryocytes and endothelial cells

Turner, Elizebeth C. ; Kinsella, B. Therese (Elsevier, 2009-02-27)

Prostacyclin plays a central role in haemostasis, inflammation and nociception. However, the factors regulating expression of the prostacyclin receptor (IP) gene in humans, or in other species, have not been identified. ...

Now showing items 1-20 of 21

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