Browsing by Author "Gannon, AnneMarie"

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Regulated expression of the α isoform of the human thromboxane A2 receptor during megakaryocyte differentiation : a coordinated role for WT1, Egr1 & Sp1

Gannon, AnneMarie ; Turner, Elizebeth C. ; Reid, Helen M. ; Kinsella, B. Therese (Elsevier, 2009-11-20)

Thromboxane plays an essential role in haemostasis, regulating platelet aggregation and vessel tone. In humans, it signals through the TPalpha and TPbeta isoforms that are transcriptionally regulated by distinct promoters, ...
The Wilms’ tumor suppressor protein WT1 acts as a key transcriptional repressor of the human thromboxane A2 receptor gene in megakaryocytes

Gannon, AnneMarie ; Kinsella, B. Therese (Wiley-Blackwell, 2009-11)

In humans, TPα and TPβ isoforms of the thromboxane A2 receptor are transcriptionally regulated by distinct promoters, designated Prm1 and Prm3. Previous investigations identified two upstream repressor regions (URR) 1 and ...

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